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정신 건강과 N-아세틸 시스테인(NAC) 연구에서 밝혀진 진실은?

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 N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์€ ์‹œ์Šคํ…Œ์ธ์ด๋ผ๋Š” ์•„๋ฏธ๋…ธ์‚ฐ์˜ ํ•œ ํ˜•ํƒœ๋กœ, ์•„์„ธํŠธ์•„๋ฏธ๋…ธํŽœ์ด๋‚˜ ํŒŒ๋ผ์„ธํƒ€๋ชฐ๊ณผ ๊ฐ™์€ ์•ฝ๋ฌผ์„ ๊ณผ๋‹ค ๋ณต์šฉํ•œ ์‚ฌ๋žŒ์„ ์น˜๋ฃŒํ•˜๋Š” ์‘๊ธ‰ ์˜์•ฝ์œผ๋กœ ๋„๋ฆฌ ์‚ฌ์šฉ๋˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ด์™ธ์—๋„ ํ˜„์žฌ ์˜ํ•™๊ณ„์—์„œ๋Š” ์ด๋Ÿฌํ•œ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์ด ์ฃผ์š” ์šฐ์šธ ์žฅ์• ๋‚˜ ์–‘๊ทน์„ฑ ์žฅ์• , ์กฐํ˜„๋ณ‘์ด๋‚˜ ๋ฐœ๋ชจ๋ฒฝ(์ž๊ธฐ ์ž์‹ ์˜ ํ„ธ์„ ์žก์•„ ๋œฏ๋Š” ๋ณ‘์  ์ถฉ๋™์„ฑ: ์—ญ์ž์ฃผ) ๋ฐ ๊ธฐํƒ€ ์—ฌ๋Ÿฌ ์ถฉ๋™ ์กฐ์ ˆ ์žฅ์• ์™€ ์•ฝ๋ฌผ ๋‚จ์šฉ ์žฅ์•  ์น˜๋ฃŒ์— ๋ฏธ์น˜๋Š” ํšจ๋Šฅ์— ๋Œ€ํ•˜์—ฌ ์œ„์•ฝ(ํšจ๋Šฅ์ด ์—†๋Š” ์•ฝ๋ฌผ: ์—ญ์ž์ฃผ)๊ณผ ๋Œ€์กฐํ•˜๋Š” ์—ฐ๊ตฌ๊ฐ€ ํ™œ๋ฐœํ•˜๊ฒŒ ์ด๋ฃจ์–ด์ง€๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ผ๋ฐ˜์ ์œผ๋กœ ์ •์‹  ์žฅ์•  ์น˜๋ฃŒ์— ์‚ฌ์šฉ๋˜๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์˜ ์–‘์€ ํ™˜์ž๊ฐ€ ํฐ ๋ถ€์ž‘์šฉ ์—†์ด ์ž˜ ๊ฒฌ๋”œ ์ˆ˜ ์žˆ๋Š” ์ •๋„์ง€๋งŒ, ๊ฒฝ์šฐ์— ๋”ฐ๋ผ ๊ตฌ์—ญ์งˆ์„ ํ•˜๊ฑฐ๋‚˜, ํ† ํ•˜๋Š” ํ™˜์ž, ์†์ด ์“ฐ๋ฆฌ๊ฑฐ๋‚˜, ๋ฐœ์ง„ ๋˜๋Š” ๋ฐœ์—ด์„ ์ผ์œผํ‚ค๋Š” ์‚ฌ๋žŒ๋„ ์žˆ์Šต๋‹ˆ๋‹ค. N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์ด ์ฃผ์š” ์ •์‹  ์žฅ์• ์— ๋ฏธ์น˜๋Š” ์žฅ์ ์„ ์กฐ์‚ฌํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ์„œ๋กœ ์ƒ๋ฐ˜๋œ ๊ฒฐ๊ณผ๋„ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ์ด๋ฒˆ ๋ธ”๋กœ๊ทธ์—์„œ๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ ์—ฐ๊ตฌ์— ๋Œ€ํ•ด์„œ ๊ฐ„๋‹จํžˆ ์š”์•ฝํ•ด ๋ณด๊ฒ ์Šต๋‹ˆ๋‹ค.

N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ(NAC): ์ž‘์šฉ ๋ฉ”์ปค๋‹ˆ์ฆ˜

N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ(NAC)์€ ์šฐ๋ฆฌ ๋ชธ์—์„œ ๋…์„ฑ ์„ฑ๋ถ„์„ ๋ฐœํœ˜ํ•˜๋Š” ๋ถ„์ž์ธ ๋ฐ˜์‘์„ฑ ์‚ฐ์†Œ ๋ถ„์ž(์˜ˆ: โ€˜์ž์œ  ๋ผ๋””์นผโ€™)๋ฅผ ์ œ๊ฑฐํ•˜๋Š”๋ฐ ํ•„์ˆ˜์ ์ธ ์—ญํ• ์„ ๋‹ด๋‹นํ•˜๋Š” ์ฃผ์š” ํ•ญ์‚ฐํ™” ๋ฌผ์งˆ์ธ ๊ธ€๋ฃจํƒ€ํ‹ฐ์˜จ(Glutathione) ์ˆ˜์น˜๋ฅผ ํšŒ๋ณต์‹œํ‚ค๋ฏ€๋กœ, ๋ฐ˜์‘์„ฑ์ด ๋†’์€ ๋ถ„์ž๊ฐ€ ์ผ์œผํ‚ค๋Š” ์„ธํฌ ๋‚ด ์†์ƒ์„ ์ค„์—ฌ ์ค๋‹ˆ๋‹ค. ๋˜ํ•œ, ์ธ์ฒด์˜ ์ฃผ์š” ํ•ญ์‚ฐํ™” ๊ธ€๋ฃจํƒ€ํ‹ฐ์˜จ ์ˆ˜์ค€์„ ํšŒ๋ณต์‹œ์ผœ ๋…์„ฑ ๋ฐ˜์‘์„ฑ ์‚ฐ์†Œ ๋ถ„์ž (์˜ˆ :โ€˜์ž์œ  ๋ผ๋””์นผโ€™)๋ฅผ ์ œ๊ฑฐํ•˜๋Š” ๋ฐ ํ•„์ˆ˜์ ์ธ ์—ญํ• ์„ ์ˆ˜ํ–‰ํ•˜์—ฌ ๋†’์€ ๋ฐ˜์‘์„ฑ ๋ถ„์ž๋กœ ๋ฐœ์ƒํ•œ ์„ธํฌ ๋‚ด์˜ ์†์ƒ์„ ์ค„์—ฌ ์ค๋‹ˆ๋‹ค. IL-6๋‚˜ ์ข…์–‘ ๊ดด์‚ฌ ์ธ์ž-์•ŒํŒŒ๋Š” ์กฐํ˜„๋ณ‘์ด๋‚˜ ์–‘๊ทน์„ฑ ์žฅ์• , ์šฐ์šธ์ฆ์˜ ๋ฐœ๋ณ‘๊ณผ ๊ด€๋ จ๋œ ๋ฌผ์งˆ์ธ๋ฐ, N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์€ ์ด๋Ÿฌํ•œ ๋ฌผ์งˆ์˜ ํ˜ˆ์ค‘ ๋†๋„๋ฅผ ๊ฐ์†Œ์‹œํ‚จ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์€ ์‹œ์Šคํ…Œ์ธ ์ˆ˜์น˜๋ฅผ ์ฆ๊ฐ€ ์‹œ์ผœ, ๊ธ€๋ฃจํƒ€๋ฉ”์ดํŠธ์™€ ๋„ํŒŒ๋ฏผ์˜ ํ•ฉ์„ฑ ๊ฒฝ๋กœ๋ฅผ ์กฐ์ ˆํ•˜๊ณ  ๋„ํŒŒ๋ฏผ ๋ฐฉ์ถœ์„ ์ž๊ทนํ•ฉ๋‹ˆ๋‹ค.

NAC, ์ฃผ์š” ์šฐ์šธ ์žฅ์•  (MDD) ๋ฐ ์–‘๊ทน์„ฑ ์žฅ์• 

์ฃผ์š” ์šฐ์šธ ์žฅ์• ๋‚˜ ์–‘๊ทน์„ฑ ์žฅ์•  ๋ฐ ๊ธฐํƒ€ ์ •์‹  ์žฅ์• ๋กœ ์ง„๋‹จ ๋ฐ›์€ ํ™˜์ž๊ฐ€ ๋Š๋ผ๋Š” ์šฐ์šธํ•œ ๊ฐ์ •์— ๋ฏธ์น˜๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ(NAC)์˜ ํšจ๊ณผ๋ฅผ ์œ„์•ฝ๊ณผ ๋น„๊ตํ•œ ์—ฐ๊ตฌ๋ฅผ ๋ฉ”ํƒ€ ๋ถ„์„ํ•˜๊ณ  ์ฒด๊ณ„์ ์œผ๋กœ ๊ฒ€ํ† ํ•œ ๊ฒฐ๊ณผ, ์—ฐ๊ตฌ ๊ทœ๋ชจ์™€ ๋ฐฉ๋ฒ•๋ก ์  ์—„๊ฒฉ์„ฑ ๊ธฐ์ค€์„ ์ถฉ์กฑํ•˜๋Š” 5๊ฑด์˜ ์—ฐ๊ตฌ ์กฐ์‚ฌ๋ฅผ ์ข…ํ•ฉํ•˜์˜€์Šต๋‹ˆ๋‹ค(์ด์ฐธ์—ฌ์ž 574๋ช…). ๊ทธ ๊ฒฐ๊ณผ, N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ๋งŒ์„ 12์ฃผ์—์„œ 24์ฃผ ๋™์•ˆ ๋‹จ๋…์œผ๋กœ ๋ณต์šฉํ•œ ์‚ฌ๋žŒ๋“ค์€ ์ž์‹ ์˜ ์ •์‹  ์žฅ์• ์™€ ๊ด€๊ณ„์—†์ด, ์šฐ์šธ์ฆ ์ฆ์ƒ์ด ์ ๋‹นํžˆ ๊ฐœ์„ ๋˜๊ณ  ์ „๋ฐ˜์ ์ธ ๊ธฐ๋Šฅ์ด ํ–ฅ์ƒ๋˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ์ด์ค‘ ๋งน๊ฒ€์œผ๋กœ 16์ฃผ๊ฐ„ ์ง„ํ–‰๋œ ๋ณด์กฐ ์—ฐ๊ตฌ(์ฐธ์—ฌ์ž 252๋ช…)์—์„œ๋Š” ์ฃผ์š” ์šฐ์šธ์ฆ์œผ๋กœ ์ง„๋‹จ๋ฐ›์€ ์„ฑ์ธ ํ™˜์ž๋ฅผ ๋ฌด์ž‘์œ„๋กœ ์ง€์ •ํ•˜์—ฌ ํ†ต์ƒ์ ์œผ๋กœ ๋ณต์šฉํ•˜๋Š” ํ•ญ์šฐ์šธ์ œ์™€ ํ•จ๊ป˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์ด๋‚˜ ์œ„์•ฝ์„ ํ•จ๊ป˜ ๋ณต์šฉํ•˜๋„๋ก ํ–ˆ์Šต๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ์—์„œ๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ ๋ณต์šฉํ•œ ํ™˜์ž๊ตฐ์—์„œ (12์ฃผ๊ฐ€ ์•„๋‹Œ) 16์ฃผ ๋ฌด๋ ต๋ถ€ํ„ฐ ์ฆ์ƒ ๊ฐœ์„ ์˜ ํšจ๊ณผ๊ฐ€ ๋”์šฑ ํฌ๊ฒŒ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•œ ํ™˜์ž๋“ค ์ค‘์—์„œ๋Š” ์œ„์žฅ ๋ถˆํŽธ์„ ๋ณด๊ณ ํ•œ ๋น„์œจ์ด ๋น„๊ต์  ๋†’๊ฒŒ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.

6 ๊ฐœ์›”๊ฐ„ ์‹ค์‹œ๋œ ๋˜ ๋‹ค๋ฅธ ์ด์ค‘ ๋งน๊ฒ€ ๋ณด์กฐ ์—ฐ๊ตฌ(์ฐธ์—ฌ์ž 75๋ช…)์—์„œ๋Š” ์–‘๊ทน์„ฑ ์žฅ์•  ์ง„๋‹จ์„ ๋ฐ›์€ ์„ฑ์ธ ํ™˜์ž๋ฅผ ๋ฌด์ž‘์œ„๋กœ ์ง€์ •ํ•˜์—ฌ ํ‰์ƒ์‹œ์˜ ์น˜๋ฃŒ๋ฅผ ๊ณ„์†ํ•ด์„œ ๋ฐ›์œผ๋ฉด์„œ ํ•˜๋ฃจ 2000mg์˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์ด๋‚˜ ์œ„์•ฝ์„ ๋ณต์šฉํ•˜๋„๋ก ํ–ˆ์Šต๋‹ˆ๋‹ค. ๊ทธ ๊ฒฐ๊ณผ, N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•œ ํ™˜์ž๋Š” ์œ„์•ฝ์„ ๋ณต์šฉํ•œ ํ™˜์ž์— ๋น„ํ•ด ์šฐ์šธ์ฆ ์ฆ์ƒ์ด ์ง€์†์ ์œผ๋กœ ํ˜„์ €ํ•˜๊ฒŒ ๊ฐ์†Œํ•˜๊ณ , ์ „๋ฐ˜์ ์ธ ๊ธฐ๋Šฅ์„ฑ์ด ํ–ฅ์ƒ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ ๋ณต์šฉ์„ ์ค‘๋‹จํ•˜์ž ์ด๋Ÿฌํ•œ ๊ฐœ์„  ํšจ๊ณผ๋Š” 1๊ฐœ์›” ํ›„์— ์‚ฌ๋ผ์กŒ์Šต๋‹ˆ๋‹ค. 2๊ฐœ์›”๊ฐ„ ์ง„ํ–‰๋œ ๋ฌด์ž‘์œ„์  ์„ ๋ณ„์— ์˜ํ•œ ์œ„์•ฝ ๋Œ€์กฐ ์—ฐ๊ตฌ์˜ ์˜คํ”ˆ ๋ผ๋ฒจ ์‹œํ—˜ ๋‹จ๊ณ„์—์„œ๋Š”, ์–‘๊ทน์„ฑ ์žฅ์•  ์ง„๋‹จ์„ ๋ฐ›๊ณ  ์ค‘๊ฐ„ ์ •๋„์˜ ์šฐ์šธ์ฆ ์ฆ์ƒ์„ ๋ณด์ด๋Š” 149๋ช…์˜ ํ™˜์ž์—๊ฒŒ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ (1mg, ํ•˜๋ฃจ ๋‘ ๋ฒˆ) ๋ณต์šฉํ•˜๋„๋ก ํ–ˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ๊ฐ€ ์ข…๋ฃŒ๋  ๋ฌด๋ ต, N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•œ ํ™˜์ž์˜ ์šฐ์šธ์ฆ ์ฆ์ƒ์ด ํ˜„์ €ํ•˜๊ฒŒ ๊ฐ์†Œํ•˜์˜€๊ณ  ๊ธฐ๋Šฅ์„ฑ๊ณผ ์‚ถ์˜ ์งˆ์„ ๋‚˜ํƒ€๋‚ด๋Š” ์ง€ํ‘œ๊ฐ€ ๊ฐœ์„ ๋œ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜, ๊ฐ™์€ ์—ฐ๊ตฌ์ง„์ด ์ง„ํ–‰ํ•œ ์ด์ค‘ ๋งน๊ฒ€, ์œ„์•ฝ ๋Œ€์กฐ ์—ฐ๊ตฌ์˜ ๋ณธ ๋‹จ๊ณ„์—์„œ๋Š” 149๋ช…์˜ ์•ˆ์ •์  ์–‘๊ทน์„ฑ ์žฅ์•  ํ™˜์ž๊ฐ€ ํ‰์ƒ์‹œ์˜ ์น˜๋ฃŒ๋ฅผ ๊ณ„์†ํ•ด์„œ ๋ฐ›์œผ๋ฉด์„œ ๋ฌด์ž‘์œ„์ ์œผ๋กœ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ(ํ•˜๋ฃจ 2mg)์„ ๋ณต์šฉํ–ˆ์ง€๋งŒ, ์žฌ๋ฐœ๋ฅ ์ด๋‚˜ ์‚ถ์˜ ์งˆ์ด ์œ„์•ฝ์„ ๋ณต์šฉํ•œ ํ™˜์ž์— ๋น„ํ•ด ์œ ์˜๋ฏธํ•œ ๊ฐœ์„ ์„ ๋ณด์ด์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ ์ข…๋ฃŒ ์‹œ์ ์—์„œ๋Š” ์ฆ์ƒ์„ ๋‚˜ํƒ€๋‚ด๋Š” ์ ์ˆ˜๊ฐ€ ๋‚ฎ์€ ์ƒํƒœ๋ฅผ ์œ ์ง€ํ•˜์˜€์ง€๋งŒ, N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•œ ํ™˜์ž์™€ ์œ„์•ฝ์„ ๋ณต์šฉํ•œ ํ™˜์ž ๊ฐ„์˜ ๋ณ€ํ™”๋Š” ์ตœ์†Œ ์ˆ˜์ค€์— ๊ทธ์ณค์Šต๋‹ˆ๋‹ค.

์ตœ๊ทผ์— ๋ฐœํ‘œ๋œ 16์ฃผ๊ฐ„์˜ ์ด์ค‘ ๋งน๊ฒ€ ๋ณด์กฐ ์—ฐ๊ตฌ(์ฐธ์—ฌ์ž 181๋ช…)์—์„œ๋Š” ๊ธ‰์„ฑ ์šฐ์šธ ์ฆ์ƒ์„ ๋ณด์ด๋Š” ์–‘๊ทน์„ฑ ์žฅ์•  ์„ฑ์ธ ํ™˜์ž๋ฅผ ๋ฌด์ž‘์œ„๋กœ ์ง€์ •ํ•˜์—ฌ ํ‰์ƒ์‹œ์˜ ์น˜๋ฃŒ๋ฅผ ๊ณ„์†ํ•ด์„œ ๋ฐ›์œผ๋ฉด์„œ ํ•˜๋ฃจ 2000mg์˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์ด๋‚˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ๊ณผ ๊ธฐ๋Šฅ์„ฑ ์‹ํ’ˆ, ๋˜๋Š” ์œ„์•ฝ์„ ๋ณต์šฉํ•˜๋„๋ก ํ–ˆ์Šต๋‹ˆ๋‹ค. N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ๊ณผ ๋ณ‘์šฉํ•œ ๊ธฐ๋Šฅ์„ฑ ์‹ํ’ˆ์€  l- ์นด๋ฅด๋‹ˆํ‹ด๊ณผ ์œ ๋น„ํ€ด๋…ผ (์ฝ”์—”์ž์ž„ Q10), ์•ŒํŒŒ ๋ฆฌํฌ์‚ฐ (ALA) ๋ฐ ์ •์ƒ์ ์ธ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ๊ธฐ๋Šฅ์— ํ•„์š”ํ•œ ๋ณด์กฐ ์ธ์ž๋ฅผ ํฌํ•จํ•˜์—ฌ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ๊ธฐ๋Šฅ์— ์œ ๋ฆฌํ•œ ์˜ํ–ฅ์„ ๋ฏธ์น˜๋Š” ๊ฒƒ์œผ๋กœ ์•Œ๋ ค์ง„ 16๊ฐ€์ง€ ๋ฌผ์งˆ๋กœ ๊ตฌ์„ฑ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ๊ฐ€ ์ข…๋ฃŒ๋  ๋ฌด๋ ต, ๋ชฝ๊ณ ๋ฉ”๋ฆฌ-์•„์Šค๋ฒ„๊ทธ ์šฐ์šธ ์ฆ์ƒ ์šฐ์šธ ํ‰๊ฐ€ ์ฒ™๋„(MADRS)๋ฅผ ์ด์šฉํ•˜์—ฌ ์ธก์ •ํ•œ ๊ฒฐ๊ณผ, ๊ฐ ์น˜๋ฃŒ๊ตฐ ์‚ฌ์ด์˜ ์–‘๊ทน์„ฑ ์šฐ์šธ ์ฆ์ƒ์˜ ์‹ฌ๊ฐ๋„๋Š” ์•„๋ฌด๋Ÿฐ ์ฐจ์ด๋ฅผ ๋ณด์ด์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜, ์น˜๋ฃŒ๋ฅผ ์ค‘๋‹จํ•œ ํ›„ 20์ฃผ ๊ฒฝ๊ณผ ์‹œ์ ์—๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ๊ณผ ๊ธฐ๋Šฅ์„ฑ ์‹ํ’ˆ์„ ๋ณ‘์šฉํ•˜์—ฌ ์„ญ์ทจํ–ˆ๋˜ ๊ทธ๋ฃน์˜ ํ™˜์ž๋“ค์ด ์œ„์•ฝ์„ ์„ญ์ทจํ–ˆ๋˜ ๊ทธ๋ฃน์˜ ํ™˜์ž์— ๋น„ํ•ด ์ž„์ƒ์ ์œผ๋กœ ํ˜„์ €ํ•˜๊ฒŒ ๊ฐœ์„ ๋˜๋Š” ๊ฒฐ๊ณผ๋ฅผ ๋ณด์˜€์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์ง„์€ ์ด๋Ÿฌํ•œ ๊ฒฐ๊ณผ๋ฅผ ๋ณ‘์šฉ ์น˜๋ฃŒ๋ฒ•์˜ ํšจ๊ณผ๊ฐ€ ์ง€์—ฐ๋˜์–ด ๋‚˜ํƒ€๋‚ฌ๊ฑฐ๋‚˜, ์น˜๋ฃŒ ์ค‘๋‹จ ํ›„ ๋‚˜ํƒ€๋‚˜๋Š” ์ž„์ƒ์  ๊ฐœ์„ ์˜ ๊ฒฐ๊ณผ์ผ ๊ฐ€๋Šฅ์„ฑ์ด ์žˆ๋‹ค๊ณ  ์„ค๋ช…ํ–ˆ์Šต๋‹ˆ๋‹ค.

NAC์™€ ์กฐํ˜„๋ณ‘

์–‘๊ทน์„ฑ ์žฅ์• ์™€ ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ ์กฐํ˜„๋ณ‘ ํ™˜์ž์—ญ์‹œ ๊ฑด๊ฐ•ํ•œ ์‚ฌ๋žŒ์— ๋น„ํ•ด ์‚ฐํ™” ์ž‘์šฉ์— ์˜ํ•œ ์ŠคํŠธ๋ ˆ์Šค๊ฐ€ ๋น„๊ต์  ์‹ฌ๊ฐํ•˜๊ฒŒ ๋‚˜ํƒ€๋‚  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์‚ฐํ™” ์ž‘์šฉ์— ์˜ํ•œ ์ŠคํŠธ๋ ˆ์Šค์˜ ์ •๋„๋Š” ์‹ ๊ฒฝ ์„ธํฌ๋ง‰์˜ ๋ณ€ํ™” ๋ฐ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„์˜ ๊ธฐ๋Šฅ ์žฅ์• ๋กœ ์ด์–ด์ ธ, ์กฐํ˜„๋ณ‘์œผ๋กœ ์ง„๋‹จ๋ฐ›์€ ํ™˜์ž์˜ ์ฆ์ƒ์„ ๋”์šฑ ์•…ํ™”์‹œํ‚ฌ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์กฐํ˜„๋ณ‘ ํ™˜์ž๋Š” ์ „์ „๋‘์—ฝ ํ”ผ์งˆ(Prefrontal cortex)์˜ ๊ธ€๋ฃจํƒ€๋ฉ”์ดํŠธ ์ˆ˜์น˜ ๊ฐ์†Œ๋ฅผ ๋ณด์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ์„ญ์ทจํ•  ๊ฒฝ์šฐ, ์ „์ฒด์ ์ธ ์‚ฐํ™” ๊ณผ์ •์— ์˜ํ•œ ์ŠคํŠธ๋ ˆ์Šค๋Š” ๊ฐ์†Œํ•˜๊ณ , ์ค‘์ถ” ์‹ ๊ฒฝ ์งˆํ™˜์ž(CNS)์˜ ๊ธ€๋ฃจํƒ€๋ฉ”์ดํŠธ ์ˆ˜์น˜๋Š” ์ฆ๊ฐ€ํ•˜๋ฏ€๋กœ ์ •์‹  ์งˆํ™˜์˜ ์ฆ์ƒ์ด ์™„ํ™”๋˜๋Š” ๊ฒƒ์ž…๋‹ˆ๋‹ค. 6๊ฐœ์›” ๋™์•ˆ ๋Œ€๊ทœ๋ชจ๋กœ ์ด๋ฃจ์–ด์ง„ ํ•œ ์ด์ค‘ ๋งน๊ฒ€ ๋ณด์กฐ ์—ฐ๊ตฌ(์ฐธ์—ฌ์ž 140๋ช…)์—์„œ๋Š” ์น˜๋ฃŒ ๋ถˆ์‘์„ฑ ์กฐํ˜„๋ณ‘ ์ง„๋‹จ์„ ๋ฐ›์€ ์„ฑ์ธ์„ ๋ฌด์ž‘์œ„๋กœ ์„ ์ •ํ•˜์—ฌ, ์ •์‹ ๋ณ‘ ์น˜๋ฃŒ ์•ฝ์„ ๊ณ„์† ๋ณต์šฉํ•˜๋ฉด์„œ 1000mg์˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์ด๋‚˜ ์œ„์•ฝ์„ ํ•˜๋ฃจ์— ๋‘ ๋ฒˆ ๋ณต์šฉํ•˜๋„๋ก ํ–ˆ์Šต๋‹ˆ๋‹ค. ๊ทธ ๊ฒฐ๊ณผ, N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•œ ํ™˜์ž๋“ค์€ (๋ฌด๊ด€์‹ฌ, ์‚ฌ๊ณ ์˜ ๊ฒฐํ•, ์‚ฌํšŒ์  ์œ„์ถ•)๊ณผ ๊ฐ™์€ ๋ถ€์ •์ ์ธ ์ฆ์ƒ์ด ๊ฐœ์„ ๋˜๊ณ , ์ „๋ฐ˜์ ์ธ ๊ธฐ๋Šฅ์„ฑ์ด ํ–ฅ์ƒ๋˜๋ฉฐ, (ํ•ญ์ •์‹  ์งˆํ™˜ ์•ฝ๋ฌผ๋กœ ์ธํ•œ ์ถ”์ฒด์™ธ๋กœ ์ฆ์ƒ ๊ฐ™์€) ๋น„์ •์ƒ์  ์†Œ๊ทน์  ์šด๋™์ด ๊ฐ์†Œํ•˜๋Š” ์–‘์ƒ์„ ๋ณด์˜€์Šต๋‹ˆ๋‹ค. ๋ณด์กฐ ์•ฝ๋ฌผ๋กœ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•œ ์‚ฌ๋žŒ๋“ค์€ ์ž๊ธฐ ๊ด€๋ฆฌ๊ฐ€ ๊ฐœ์„ ๋˜๊ณ , ์‚ฌํšŒ์  ์ƒํ˜ธ์ž‘์šฉ๊ณผ ๋™๊ธฐ ๋ถ€์—ฌ๊ฐ€ ๋”์šฑ ํ™œ๋ฐœํ•ด์ง€๋ฉฐ, ์ •์„œ์ ์œผ๋กœ๋„ ๋”์šฑ ์•ˆ์ •๋˜๋Š” ๊ฒฐ๊ณผ๋ฅผ ๋ณด์˜€์Šต๋‹ˆ๋‹ค. ์–‘๊ทน์„ฑ ์žฅ์•  ๊ฐœ์„  ์—ฐ๊ตฌ์˜ ์‚ฌ๋ก€์™€ ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ, ์ด๋Ÿฌํ•œ ํšจ๊ณผ๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ ๋ณต์šฉ ์ค‘๋‹จ ํ›„ 1๊ฐœ์›”์ด ์ง€๋‚˜๋ฉด์„œ ์‚ฌ๋ผ์กŒ์Šต๋‹ˆ๋‹ค. ๋ฌด์—‡๋ณด๋‹ค๋„ ๊ด„๋ชฉํ• ๋งŒํ•œ ๊ฒƒ์€, ์—ฐ๊ตฌ ์‹œํ–‰ ์ „, ์‹œํ—˜์— ์ฐธ์—ฌํ•œ ์•ฝ 60%์˜ ํ™˜์ž๊ฐ€ ์น˜๋ฃŒ ๋ถˆ์‘์„ฑ ์กฐํ˜„๋ณ‘์˜ ๊ฐ€์žฅ ํšจ๊ณผ์ ์ธ ์น˜๋ฃŒ๋กœ ์—ฌ๊ฒจ์ง€๋Š” ๋น„์ „ํ˜•์  ์ •์‹ ๋ณ‘ ์•ฝ๋ฌผ์ธ ํด๋กœ์žํ•€(Clozapine)์„ ์ด์šฉํ•œ ์žฅ๊ธฐ ์น˜๋ฃŒ์— ๋ถ€๋ถ„์ ์œผ๋กœ ๋ฐ˜์‘ํ•˜๊ธฐ ์‹œ์ž‘ํ–ˆ๋‹ค๋Š” ์ ์ž…๋‹ˆ๋‹ค.

NAC์™€ ์ถฉ๋™ ์กฐ์ ˆ ์žฅ์• 

์†Œ๊ทœ๋ชจ๋กœ ์ง„ํ–‰๋œ ํ•œ ์ž„์ƒ ์‹œํ—˜ ๊ฒฐ๊ณผ์— ๋”ฐ๋ฅด๋ฉด, N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•  ๊ฒฝ์šฐ, ๋ฐœ๋ชจ๋ฒฝ๊ณผ ๋ณ‘์  ๋„๋ฐ•๊ณผ ๊ฐ™์€ ์ถฉ๋™ ์กฐ์ ˆ ์žฅ์• ์— ๋„์›€์ด ๋  ์ˆ˜ ์žˆ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. ์‚ฌ๋ก€ ์—ฐ๊ตฌ์™€ ์†Œ๊ทœ๋ชจ ์œ„์•ฝ ๋Œ€์กฐ ์—ฐ๊ตฌ๋ฅผ ์ข…ํ•ฉํ•ด ๋ณผ ๋•Œ, ํ•˜๋ฃจ 600mg์—์„œ 2400mg์˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ ๋ณต์šฉ์ด ๊ฐ•๋ฐ•์— ์˜ํ•ด ๋จธ๋ฆฌ๋ฅผ ์ฅ์–ด๋œฏ๋Š” ๋ฐœ๋ชจ๋ฒฝ๊ณผ ์†ํ†ฑ์„ ๋ฌผ์–ด๋œฏ๊ณ  ํ”ผ๋ถ€๋ฅผ ์žก์•„ ๋œฏ๋Š” ์ฆ์ƒ์„ ๊ฐœ์„ ํ•  ์ˆ˜ ์žˆ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. ๋˜ ๋‹ค๋ฅธ ์—ฐ๊ตฌ์—์„œ๋Š”, 8์ฃผ์— ๊ฑธ์ณ ์ง„ํ–‰๋œ ์˜คํ”ˆ ๋ผ๋ฒจ ์—ฐ๊ตฌ๋กœ๋ถ€ํ„ฐ ํ•˜๋ฃจ 1800mg์˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•˜์—ฌ ๋ณ‘๋ฆฌํ•™์  ๋„๋ฐ• ์ฆ์ƒ์ด ๊ฐœ์„ ๋œ ์‹œํ—˜ ์ฐธ์—ฌ์ž๋ฅผ ๋‹ค์‹œ ๋ฌด์ž‘์œ„๋กœ ์„ ์ •ํ•˜์—ฌ ์ถ”๊ฐ€ 6์ฃผ ๋™์•ˆ 1800mg์˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์ด๋‚˜ ์œ„์•ฝ์„ ๋ณต์šฉํ•˜๋„๋ก ํ•˜๋ฉด์„œ ์œ„์•ฝ ๋Œ€์กฐ ์—ฐ๊ตฌ๋ฅผ ์ง„ํ–‰ํ–ˆ์Šต๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ๊ฐ€ ๋๋‚  ๋ฌด๋ ต, ์œ„์•ฝ์„ ๋ณต์šฉํ•œ ์‹œํ—˜ ์ฐธ์—ฌ์ž ์ค‘ 28%๋งŒ์ด ๊ธ์ •์ ์ธ ๋ฐ˜์‘์„ ๋ณด์ธ ๋ฐ˜๋ฉด, N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•œ ์‹œํ—˜ ์ฐธ์—ฌ์ž์˜ 83%๊ฐ€ ๊ธ์ •์ ์ธ ๋ฐ˜์‘์„ ๋ณด์˜€์Šต๋‹ˆ๋‹ค.

NAC, ์•ฝ๋ฌผ ๋‚จ์šฉ๊ณผ ์ค‘๋…

์•ฝ๋ฌผ ๋‚จ์šฉ๊ณผ ์ค‘๋… ์น˜๋ฃŒ์— ๋ฏธ์น˜๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์˜ ํšจ๊ณผ์— ๋Œ€ํ•ด์„œ๋Š” ๋งŽ์€ ๋™๋ฌผ ์—ฐ๊ตฌ์™€ ์ธ๊ฐ„ ์—ฐ๊ตฌ๊ฐ€ ์ด๋ฃจ์–ด์ ธ ์žˆ์Šต๋‹ˆ๋‹ค. N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์ด ํšจ๊ณผ์ ์ธ ์ด์œ ๋Š” ๋„ํŒŒ๋ฏผ์„ ๋น„๋กฏํ•œ ์‹ ๊ฒฝ ์ „๋‹ฌ ๋ฌผ์งˆ์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๋Š” ์•ฝ๋ฌผ์„ ๋งŒ์„ฑ์ ์œผ๋กœ ์‚ฌ์šฉํ•จ์œผ๋กœ์จ ๋ฐœ์ƒํ•œ ๊ธ€๋ฃจํƒ€๋ฉ”์ดํŠธ ๊ด€๋ จ ์ƒํ™”ํ•™ ๊ฒฝ๋กœ์˜ ๋ถˆ๊ท ํ˜•์„ ์ •์ƒ์ ์œผ๋กœ ํšŒ๋ณต์‹œํ‚ค๊ธฐ ๋•Œ๋ฌธ์ž…๋‹ˆ๋‹ค. ์˜คํ”ˆ ๋ผ๋ฒจ๋กœ ์ง„ํ–‰๋œ ํ•œ ์†Œ๊ทœ๋ชจ์˜ ์—ฐ๊ตฌ(์ฐธ์—ฌ์ž 24๋ช…)์—์„œ๋Š” ๋Œ€๋งˆ์ดˆ ๋‚จ์šฉ์œผ๋กœ ์ง„๋‹จ๋œ ์„ฑ์ธ์—๊ฒŒ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ํ•˜๋ฃจ 2400mg์”ฉ ๋ณต์šฉํ•˜๋„๋ก ํ•œ ๊ฒฐ๊ณผ, ๊ฐ•๋ฐ•์  ๋Œ€๋งˆ์ดˆ ๋‚จ์šฉ์˜ ์‚ฌ๋ก€์™€ ํ•˜๋ฃจ์˜ ๋Œ€๋งˆ์ดˆ ์‚ฌ์šฉ๋Ÿ‰์ด ๋™์‹œ์— ๊ฐ์†Œํ–ˆ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. ๋˜ ๋‹ค๋ฅธ ์†Œ๊ทœ๋ชจ(์ฐธ์—ฌ์ž 29๋ช…)์˜ ์œ„์•ฝ ๋Œ€์กฐ ์—ฐ๊ตฌ์—์„œ, ๋‹ˆ์ฝ”ํ‹ด ์˜์กด์„ฑ ์„ฑ์ธ์„ ๋ฌด์ž‘์œ„๋กœ ์„ ์ •ํ•˜์—ฌ ํ•˜๋ฃจ 2400mg์˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์ด๋‚˜ ์œ„์•ฝ์„ ๋ณต์šฉํ•˜๋„๋ก ํ–ˆ์„ ๋•Œ, ์–‘์ชฝ ๊ทธ๋ฃน ๋ชจ๋‘ ๋™๋“ฑํ•œ ์ •๋„์˜ ๋ฏธ๋ฏธํ•œ ๋‹ˆ์ฝ”ํ‹ด ์‚ฌ์šฉ๋Ÿ‰ ๊ฐ์†Œ๋ฅผ ๋ณด์˜€์Šต๋‹ˆ๋‹ค. ๋˜ ๋‹ค๋ฅธ ์†Œ๊ทœ๋ชจ์˜ 6๊ฐœ์›” ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์—์„œ๋Š” ํ•˜๋ฃจ์— 1200mg์˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•œ ๊ฒฝ์šฐ, ๋‹ˆ์ฝ”ํ‹ด์ด DNA์— ๋ฏธ์น˜๋Š” ์œ ํ•ดํ•œ ์˜ํ–ฅ์„ ๊ฐ์†Œ ์‹œ์ผœ, ๋งŒ์„ฑ ํก์—ฐ์ž์˜ ์•” ์œ„ํ—˜์„ ์ค„์ผ ์ˆ˜ ์žˆ๋Š” ๊ฐ€๋Šฅ์„ฑ์„ ๋ณด์˜€๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค.

NAC์™€ ๊ฐ•๋ฐ• ์žฅ์• 

๊ฐ•๋ฐ• ์žฅ์•  ํ™˜์ž ์ฆ์ƒ์˜ ์‹ฌ๊ฐ์„ฑ์€ ์‚ฐํ™” ์ž‘์šฉ์œผ๋กœ ์ธํ•œ ์ŠคํŠธ๋ ˆ์Šค์™€ ๊ด€๋ จ์ด ์žˆ๋‹ค๋Š” ๊ฐ€์„ค์ด ์žˆ์Šต๋‹ˆ๋‹ค. ํ˜„์žฌ๊นŒ์ง€, ๊ฐ•๋ฐ• ์žฅ์• ์— ๋ฏธ์น˜๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์˜ ํšจ๊ณผ์— ๋Œ€ํ•ด ๋ฐœํ‘œํ•œ ์—ฐ๊ตฌ๋Š” 1๊ฑด์— ๋ถˆ๊ณผํ•ฉ๋‹ˆ๋‹ค. ์ด ์—ฐ๊ตฌ์—์„œ, ๋‚œ์น˜์„ฑ ๊ฐ•๋ฐ• ์žฅ์• ์˜ ์„ฑ์ธ์„ ํ”Œ๋ฃจ๋ณต์‚ฌ๋ฏผ๊ณผ ํ•˜๋ฃจ 3mg์˜ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์œผ๋กœ ์น˜๋ฃŒํ•  ๊ฒฝ์šฐ, ๊ฐ•๋ฐ•์„ฑ๊ณผ ์ถฉ๋™์„ฑ์— ์žˆ์–ด ์œ ์˜๋ฏธํ•˜๊ณ  ์ง€์†์ ์ธ ๊ฐœ์„ ์ด ๋‚˜ํƒ€๋‚ฌ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค.

NAC์— ๋Œ€ํ•˜์—ฌ ๋ฐํ˜€์ง€๋Š” ์‚ฌ์‹ค๊ณผ ์ •์‹  ๊ฑด๊ฐ•์— ๋ฏธ์น˜๋Š” ํšจ๊ณผ

์‚ฐํ™” ๋ฐ˜์‘์— ์˜ํ•œ ์ŠคํŠธ๋ ˆ์Šค๋Š” ์–‘๊ทน์„ฑ ์žฅ์• ์™€ ์ถฉ๋™ ์กฐ์ ˆ ์žฅ์• , ์กฐํ˜„๋ณ‘ ๋ฐ ์•ฝ๋ฌผ ๋‚จ์šฉ ์žฅ์• ์™€ ๊ฐ™์ด ๋‹ค์–‘ํ•œ ์ •์‹  ์žฅ์• ๋ฅผ ์ผ์œผํ‚ค๋Š” ๊ณตํ†ต์ ์ธ ์›์ธ์ž…๋‹ˆ๋‹ค. N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ ์—ฐ๊ตฌ๋กœ๋ถ€ํ„ฐ ๋ฐํ˜€์ง€๋Š” ์ƒˆ๋กœ์šด ์‚ฌ์‹ค๋“ค์€ ๋ชจ๋‘ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ ๋ณด์ถฉ์ œ๋ฅผ ๋ณต์šฉํ•  ๊ฒฝ์šฐ, ์šฐ๋ฆฌ ๋ชธ์˜ ์ฃผ์š” ํ•ญ์‚ฐํ™” ๋ฌผ์งˆ์ธ ๊ธ€๋ฃจํƒ€ํ‹ฐ์˜จ์˜ ๋†๋„๋ฅผ ํšŒ๋ณตํ•˜๊ณ , ํ˜ˆ์ฒญ ๋‚ด์˜ ์ „ ์—ผ์ฆ ๋ฌผ์งˆ์ธ ์‚ฌ์ดํ† ์นด์ธ์˜ ๋†๋„๋ฅผ ๋‚ฎ์ถ”๋ฉฐ, ๊ธ€๋ฃจํƒ€๋ฉ”์ดํŠธ์™€ ๋„ํŒŒ๋ฏผ์˜ ์ƒํ•ฉ์„ฑ ๊ฒฝ๋กœ๋ฅผ ๋น„๋กฏํ•œ ๋‹ค์–‘ํ•œ ๋ฉ”์ปค๋‹ˆ์ฆ˜์„ ํ†ตํ•ด ์ด๋Ÿฌํ•œ ์žฅ์•  ๊ด€๋ จ ์ฆ์ƒ์˜ ์‹ฌ๊ฐ์„ฑ์„ ๊ฐ์†Œ์‹œํ‚จ๋‹ค๋Š” ์‚ฌ์‹ค์„ ๋’ท๋ฐ›์นจํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ๋ชจ๋“  ์—ฐ๊ตฌ์˜ ๊ฒฐ๊ณผ๊ฐ€ ๋ฐ˜๋“œ์‹œ ์ผ์น˜ํ•˜๋Š” ๊ฒƒ์€ ์•„๋‹ˆ์ง€๋งŒ, ํ˜„์žฌ๊นŒ์ง€์˜ ์ถ•์ ๋œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๋ณต์šฉํ•  ๊ฒฝ์šฐ, ์–‘๊ทน์„ฑ ์žฅ์• ์™€ ์กฐํ˜„๋ณ‘, ์ถฉ๋™ ์กฐ์ ˆ ์žฅ์•  ๋ฐ ์•ฝ๋ฌผ ๋‚จ์šฉ์— ๊ธ์ •์ ์ธ ํ˜œํƒ์„ ๋ฏธ์น˜๋Š” ๊ฒฝํ–ฅ์„ ๋ณด์ด๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ตœ๊ทผ์— ๋ฐœํ‘œ๋œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์— ๋”ฐ๋ฅด๋ฉด N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์„ ๊ธฐ๋Šฅ์„ฑ ๋ณด์กฐ์ œ์™€ ํ•จ๊ป˜ ๋ณต์šฉํ•  ๊ฒฝ์šฐ, ์น˜๋ฃŒ๋ฅผ ์ค‘๋‹จํ•œ ์ดํ›„์—๋„ ํ˜œํƒ์ด ์ง€์—ฐ๋˜์–ด ๋‚˜ํƒ€๋‚  ์ˆ˜ ์žˆ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์˜ˆ๋น„ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋ฅผ ํ™•์ธํ•˜๊ณ , ๋‹ค์–‘ํ•œ ์ •์‹  ์žฅ์•  ์น˜๋ฃŒ์— ๊ฐ€์žฅ ๋„์›€์ด ๋˜๋Š” N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ ์šฉ๋Ÿ‰์„ ๊ฒฐ์ •ํ•˜๋ฉฐ, ๋ฐ˜์‘์— ๋”ฐ๋ฅด๋Š” ์ŠคํŠธ๋ ˆ์Šค๋ฅผ ์™„ํ™”ํ•˜๋ฉฐ, ์•ˆ์ •์ œ๋‚˜ ํ•ญ์šฐ์šธ์ œ ๋˜๋Š” ์‚ฐํ™” ๋ฐ˜์‘์— ๋”ฐ๋ฅด๋Š” ์ŠคํŠธ๋ ˆ์Šค ๊ฐ์†Œ์™€ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ๊ธฐ๋Šฅ์„ ์ตœ์ ํ™”๋ฅผ ์œ„ํ•œ ๊ธฐ๋Šฅ์„ฑ ์‹ํ’ˆ๊ณผ ํ•จ๊ป˜ ๋ณ‘์šฉ ์„ญ์ทจํ•ด๋„ ์ข‹์€ N-์•„์„ธํ‹ธ ์‹œ์Šคํ…Œ์ธ์˜ ๋ณต์šฉ๋Ÿ‰์„ ๊ฒฐ์ •ํ•˜๋ ค๋ฉด ๋Œ€๊ทœ๋ชจ์˜ ์œ„์•ฝ ๋Œ€์กฐ ์—ฐ๊ตฌ๊ฐ€ ์•ž์œผ๋กœ๋„ ๋”์šฑ ๋งŽ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.

์ฐธ๊ณ ๋ฌธํ—Œ

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  2. Berk M, Turner A, Malhi GS, Ng CH, Cotton SM, et al (2019) A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo. BMC Med. 25;17(1):18. 
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  4. Berk M, Dean O, Cotton SM, Gama CS, Kapczinski F, et al (2011) The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial. J Affect Disord. 2011 Dec;135(1-3):389-94. 
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