์ด ์„ธ์…˜์— ๋Œ€ํ•œ ๊ธฐ๋ณธ ์„ค์ •์ด ์—…๋ฐ์ดํŠธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ๊ณ ๊ฐ๋‹˜์˜ ๊ณ„์ • ์„ค์ •์„ ์˜๊ตฌ์ ์œผ๋กœ ๋ณ€๊ฒฝํ•˜๋ ค๋ฉด ๋‚ด ๊ณ„์ •์œผ๋กœ ์ด๋™ํ•˜์„ธ์š”.
์›ํ•˜๋Š” ์ˆ˜๋ น ๊ตญ๊ฐ€ ๋˜๋Š” ์‚ฌ์šฉ ์–ธ์–ด๋ฅผ ๋‚ด ๊ณ„์ •์—์„œ ์–ธ์ œ๋“ ์ง€ ์—…๋ฐ์ดํŠธํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
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기억력과 뇌 건강에 좋은 보충제

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๋‚˜์ด๊ฐ€ ๋“ค์ˆ˜๋ก ๊ธฐ์–ต๋ ฅ๊ณผ ๋‡Œ ๊ธฐ๋Šฅ์ด ์ €ํ•˜๋˜๋Š” ๊ฒƒ์€ ์–ด์ฉ” ์ˆ˜ ์—†๋‹ค๊ณ  ์ƒ๊ฐํ•˜๋Š” ์‚ฌ๋žŒ์ด ๋งŽ์ง€๋งŒ ๊ทธ๊ฒƒ์€ ์‚ฌ์‹ค์ด ์•„๋‹™๋‹ˆ๋‹ค. 

๋‡Œ์„ธํฌ๋Š” ์‹ ์ฒด์—์„œ ๊ฐ€์žฅ ๋ณต์žกํ•˜๊ณ  ์ˆ˜๋ช…์ด ๊ธธ๋ฉฐ ์˜์–‘์†Œ๊ฐ€ ๋งŽ์ด ํ•„์š”ํ•œ ์„ธํฌ์ž…๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์ง€๋Šฅ, ๊ธฐ์–ต๋ ฅ, ํ–‰๋™, ์ง‘์ค‘๋ ฅ์€ ๋ชจ๋‘ ๋‡Œ์— ๊ณต๊ธ‰๋˜๋Š” ์˜์–‘์†Œ์˜ ์งˆ์— ์˜ํ–ฅ์„ ๋ฐ›์Šต๋‹ˆ๋‹ค. ๋‚˜์ด์— ์ƒ๊ด€์—†์ด ์˜์–‘ ์ƒํƒœ๋Š” ๋‡Œ ๊ธฐ๋Šฅ์„ ํ–ฅ์ƒ์‹œํ‚ค๋Š” ๋ฐ ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค.

๋‡Œ ๊ฑด๊ฐ•์„ ์ฆ์ง„ํ•˜๋Š” ๋ณด์ถฉ์ œ๋Š” ๋งŽ์Šต๋‹ˆ๋‹ค. ์ด ๊ธ€์—์„œ๋Š” ์—ฐ๊ตฌ๋ฅผ ํ†ตํ•ด ํšจ๋Šฅ์ด ์ž˜ ์ž…์ฆ๋œ ๋ณด์ถฉ์ œ ์œ„์ฃผ๋กœ ์†Œ๊ฐœํ•˜๋ ค ํ•ฉ๋‹ˆ๋‹ค. ์‹ฌํ˜ˆ๊ด€ ๊ฑด๊ฐ•๊ณผ ๋‡Œ ๊ฑด๊ฐ• ์‚ฌ์ด์—๋Š” ์•„์ฃผ ๋ฐ€์ ‘ํ•œ ๊ด€๊ณ„๊ฐ€ ์žˆ์Šต๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ ์‹ฌ์žฅ ๊ฑด๊ฐ•์„ ์ฆ์ง„ํ•˜๋Š” ์‹๋‹จ, ์ƒํ™œ์Šต๊ด€, ๋ณด์ถฉ์ œ๊ฐ€ ์ง๊ฐ„์ ‘์ ์œผ๋กœ ๋‡Œ ๊ฑด๊ฐ•์—๋„ ๋„์›€์ด ๋˜๋Š” ๊ฒƒ์€ ๋†€๋ผ์šด ์ผ์ด ์•„๋‹™๋‹ˆ๋‹ค. 

โ€Œโ€Œโ€Œโ€Œ๊ธฐ์–ต๋ ฅ์— ์ข‹์€ ๋ณด์ถฉ์ œ๋กœ๋Š” ๋น„ํƒ€๋ฏผB๊ตฐ, ์˜ค๋ฉ”๊ฐ€3, ์–‘์งˆ์˜ ์ข…ํ•ฉ๋น„ํƒ€๋ฏผ์ด ์žˆ์Šต๋‹ˆ๋‹ค. 

๋งŽ์€ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋‡Œ ๊ธฐ๋Šฅ์€ ์˜์–‘ ์ƒํƒœ์™€ ์ง์ ‘์ ์ธ ์ƒ๊ด€๊ด€๊ณ„๊ฐ€ ์žˆ์œผ๋ฉฐ ํŠนํžˆ ๋น„ํƒ€๋ฏผ, ๋ฏธ๋„ค๋ž„, ์˜ค๋ฉ”๊ฐ€3 ์ง€๋ฐฉ์‚ฐ๊ณผ ๊ฐ™์€ ํ•ต์‹ฌ ์˜์–‘์†Œ๋Š” ๋‡Œ ๊ธฐ๋Šฅ์— ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค.1-3 

ํŠนํžˆ ๊ณ ๋ น์ธต์— ์˜์–‘ ๊ฒฐํ•์ด ํ”ํ•˜๋‹ค๋Š” ์‚ฌ์‹ค์„ ๊ณ ๋ คํ•  ๋•Œ ์ •์‹ ๊ธฐ๋Šฅ ๋ฐ ๊ธฐ์–ต๋ ฅ ์žฅ์• ๋Š” ๋งŽ์€ ๊ฒฝ์šฐ ์˜์–‘ ์ƒํƒœ์™€ ๊ด€๋ จ๋œ ๋ฌธ์ œ์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

๋น„ํƒ€๋ฏผB๊ตฐ๊ณผ ์˜ค๋ฉ”๊ฐ€3 ์ง€๋ฐฉ์‚ฐ์€ ๋‡Œ ๊ธฐ๋Šฅ๊ณผ ๊ธฐ์–ต๋ ฅ์— ๋งค์šฐ ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค. ๋˜ํ•œ ๋‘ ์˜์–‘์†Œ๋ฅผ ํ•จ๊ป˜ ์„ญ์ทจํ•˜๋ฉด ๋”์šฑ ์ข‹์€ ๊ฒฐ๊ณผ๋ฅผ ์–ป์„ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

๋น„ํƒ€๋ฏผB๊ตฐ

์˜ฅ์Šคํผ๋“œ ๋Œ€ํ•™ ์ž„์ƒ์‹ ๊ฒฝ๊ณผํ•™๋ถ€(Oxfordโ€™s Department of Clinical Neurosciences)์—์„œ ์ˆ˜ํ–‰ํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ๋น„ํƒ€๋ฏผB๊ตฐ ๋ณด์ถฉ์ œ์˜ ํšจ๊ณผ๋ฅผ ์กฐ์‚ฌํ–ˆ์Šต๋‹ˆ๋‹ค.4 ์ด ์—ฐ๊ตฌ์—๋Š” ๊ฒฝ๋ฏธํ•œ ์ธ์ง€ ์žฅ์• ๊ฐ€ ์žˆ์œผ๋ฉด์„œ ์‹ฌ๊ฐํ•œ ์ •์‹ ๊ธฐ๋Šฅ ์ƒ์‹ค๋กœ ๋ฐœ์ „ํ•  ์œ„ํ—˜์ด ๋†’์€ 156๋ช…์˜ ๊ณ ๋ น ํ™˜์ž๊ฐ€ ์ฐธ์—ฌํ–ˆ์Šต๋‹ˆ๋‹ค. ํ™˜์ž๋“ค์€ ๋‘ ๊ทธ๋ฃน์œผ๋กœ ๋‚˜๋ˆ„์–ด์ ธ ํ•œ ๊ทธ๋ฃน์€ ์—ฝ์‚ฐ 800ฮผg(๋งˆ์ดํฌ๋กœ๊ทธ๋žจ), ๋น„ํƒ€๋ฏผB6 20mg, ๋น„ํƒ€๋ฏผB12 500ฮผg์„, ๋‹ค๋ฅธ ๊ทธ๋ฃน์€ ์œ„์•ฝ ๋ณด์ถฉ์ œ๋ฅผ ๋งค์ผ ์„ญ์ทจํ–ˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์—์„œ ์‚ฌ์šฉํ•œ ์—ฝ์‚ฐ๋น„ํƒ€๋ฏผB6๋น„ํƒ€๋ฏผB12์˜ ์šฉ๋Ÿ‰์€ ์ผ๋ฐ˜์ ์ธ ๊ณ ํšจ๋Šฅ ์ข…ํ•ฉ๋น„ํƒ€๋ฏผ๊ณผ ๋ฏธ๋„ค๋ž„ ๋ณด์ถฉ์ œ์— ๋“ค์–ด ์žˆ๋Š” ์„ฑ๋ถ„ ํ•จ๋Ÿ‰๊ณผ ๋น„์Šทํ•ฉ๋‹ˆ๋‹ค.

์—ฐ๊ตฌ์ง„์€ ์ž„์ƒ์‹œํ—˜ ์ „๊ณผ ์ค‘๊ฐ„์— ์ž๊ธฐ๊ณต๋ช…์˜์ƒ(MRI, Magnetic resonance imaging)์„ ์‚ฌ์šฉํ•ด ํ™˜์ž์˜ ๋‡Œ์—์„œ ํšŒ๋ฐฑ์งˆ ์œ„์ถ• ์ˆ˜์ค€์„ ์ธก์ •ํ–ˆ์Šต๋‹ˆ๋‹ค. ํšŒ๋ฐฑ์งˆ ์œ„์ถ•(์ˆ˜์ถ•)์€ ๋‡Œ ๋…ธํ™”๊ฐ€ ๊ฐ€์†ํ™”๋˜๊ณ  ์žˆ์Œ์„ ๋‚˜ํƒ€๋‚ด๋Š” ์ง•ํ›„์ž…๋‹ˆ๋‹ค. 

2๋…„๊ฐ„์˜ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์— ๋”ฐ๋ฅด๋ฉด ๋น„ํƒ€๋ฏผB๊ตฐ ๋ณด์ถฉ์ œ๋ฅผ ์„ญ์ทจํ•œ ์‚ฌ๋žŒ์€ ์œ„์•ฝ ๊ทธ๋ฃน๋ณด๋‹ค ํšŒ๋ฐฑ์งˆ ์œ„์ถ• ์ˆ˜์ค€์ด ์•ฝ 7๋ฐฐ ๋‚ฎ์€ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.

๋˜ํ•œ ํšŒ๋ฐฑ์งˆ ์œ„์ถ• ์†๋„๊ฐ€ ๋น ๋ฅธ ์‚ฌ๋žŒ์€ ํ˜ธ๋ชจ์‹œ์Šคํ…Œ์ธ(Homocysteine) ์ˆ˜์ค€์ด ๋†’์•˜๋Š”๋ฐ ๋น„ํƒ€๋ฏผB๊ตฐ ๋ณด์ถฉ์ œ๋Š” ์—ฐ๊ตฌ ์ดˆ๊ธฐ์— ํ˜ธ๋ชจ์‹œ์Šคํ…Œ์ธ ์ˆ˜์น˜๊ฐ€ ๋†’์€ ์‚ฌ๋žŒ์—๊ฒŒ ๊ฐ€์žฅ ํšจ๊ณผ์ ์ด์—ˆ์Šต๋‹ˆ๋‹ค. ์•„๋ฏธ๋…ธ์‚ฐ์ธ ๋ฉ”ํ‹ฐ์˜ค๋‹Œ์˜ ๋Œ€์‚ฌ ์‚ฐ๋ฌผ์ธ ํ˜ธ๋ชจ์‹œ์Šคํ…Œ์ธ์€ ๋น„ํƒ€๋ฏผB12๋‚˜ ๋น„ํƒ€๋ฏผB6, ์—ฝ์‚ฐ ์ˆ˜์น˜๊ฐ€ ๋‚ฎ์„ ๋•Œ ๋Š˜์–ด๋‚ฉ๋‹ˆ๋‹ค. ํ˜ธ๋ชจ์‹œ์Šคํ…Œ์ธ์€ ๋‡Œ์™€ ๋‹ค๋ฅธ ์กฐ์ง์˜ ์‚ฐํ™”์  ์†์ƒ์„ ๊ฐ€์†ํ™”ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

์˜ฅ์Šคํผ๋“œ ๋Œ€ํ•™ ์—ฐ๊ตฌ์ง„์€ ๋น„ํƒ€๋ฏผB๊ตฐ์ด ์ธ์ง€๋ ฅ ์ €ํ•˜์™€ ์—ฐ๊ด€๋œ ํŠน์ • ๋‡Œ ๋ถ€์œ„์˜ ์œ„์ถ•์„ ์–ต์ œํ•  ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๊ฒฐ๋ก ์ง€์—ˆ์Šต๋‹ˆ๋‹ค.4

์˜ค๋ฉ”๊ฐ€3

์˜ฅ์Šคํผ๋“œ ๋Œ€ํ•™์—์„œ ์‹ค์‹œํ•œ ๋˜ ๋‹ค๋ฅธ ์—ฐ๊ตฌ์—์„œ๋Š” ๋‡Œ์˜ ์˜ค๋ฉ”๊ฐ€3 ์ง€๋ฐฉ์‚ฐ ์ˆ˜์น˜๊ฐ€ ๋†’์œผ๋ฉด ๋น„ํƒ€๋ฏผB๊ตฐ์˜ ์ธ์ง€๊ธฐ๋Šฅ ๊ฐœ์„  ํšจ๊ณผ๊ฐ€ ์ฆ๊ฐ€ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.5 

์ด ์—ฐ๊ตฌ์—์„œ ๋‡Œ ๊ธฐ๋Šฅ์ด ์ €ํ•˜๋œ 250๋ช… ์ด์ƒ์˜ ์—ฐ๊ตฌ ์ฐธ์—ฌ์ž๋Š” ์˜ค๋ฉ”๊ฐ€3 ์ง€๋ฐฉ์‚ฐ์˜ ์ผ์ข…์ธ ์—์ด์ฝ”์‚ฌํŽœํƒ€์—”์‚ฐ(Eicosapentaenoic acid, EPA) ๋ฐ ๋„์ฝ”์‚ฌํ—ฅ์‚ฌ์—”์‚ฐ(Docosahexaenoic acid, DHA)์˜ ํ˜ˆ์ค‘ ์ˆ˜์น˜์™€ ์ธ์ง€๋ ฅ์„ ์ธก์ •ํ•˜๊ธฐ ์œ„ํ•œ ์ผ๋ จ์˜ ๊ฒ€์‚ฌ๋ฅผ ๋ฐ›์•˜์Šต๋‹ˆ๋‹ค. ๋‘ ๊ทธ๋ฃน์— ๋ฌด์ž‘์œ„๋กœ ๋ฐฐ์ •๋œ ํ”ผํ—˜์ž๋“ค์€ ๋น„ํƒ€๋ฏผB๊ตฐ ๋ณด์ถฉ์ œ ๋˜๋Š” ์œ„์•ฝ์„ 2๋…„๊ฐ„ ์„ญ์ทจํ–ˆ์Šต๋‹ˆ๋‹ค. ๊ทธ ํ›„ ๋‹ค์‹œ ์ธ์ง€๋ ฅ์ด ์ธก์ •๋˜์—ˆ์œผ๋ฉฐ ๊ทธ ๊ฒฐ๊ณผ๋Š” ์—ฐ๊ตฌ ์‹œ์ž‘ ์‹œ์˜ ์ธก์ •๊ฐ’๊ณผ ๋น„๊ต๋˜์—ˆ์Šต๋‹ˆ๋‹ค.

์—ฐ๊ตฌ ๊ฒฐ๊ณผ์— ๋”ฐ๋ฅด๋ฉด ์—์ด์ฝ”์‚ฌํŽœํƒ€์—”์‚ฐ ๋ฐ ๋„์ฝ”์‚ฌํ—ฅ์‚ฌ์—”์‚ฐ ์ˆ˜์น˜๊ฐ€ ๋‚ฎ์€ ์‚ฌ๋žŒ์€ ๋น„ํƒ€๋ฏผB๊ตฐ ๋ณด์ถฉ์ œ๋ฅผ ์„ญ์ทจํ•ด๋„ ํšŒ๋ฐฑ์งˆ ์œ„์ถ•์„ ๋ฐฉ์ง€ํ•˜๋Š” ํšจ๊ณผ๋ฅผ ์ „ํ˜€ ๋˜๋Š” ๊ฑฐ์˜ ์–ป์ง€ ๋ชปํ–ˆ์Šต๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ์—์ด์ฝ”์‚ฌํŽœํƒ€์—”์‚ฐ ๋ฐ ๋„์ฝ”์‚ฌํ—ฅ์‚ฌ์—”์‚ฐ ๊ธฐ์ค€ ์ˆ˜์น˜๊ฐ€ ๋†’์€ ์‚ฌ๋žŒ์˜ ๊ฒฝ์šฐ์—๋Š” ๋น„ํƒ€๋ฏผB๊ตฐ ๋ณด์ถฉ์ œ๊ฐ€ ์œ„์•ฝ์— ๋น„ํ•ด ์ธ์ง€๋ ฅ ์ €ํ•˜๋ฅผ ์˜ˆ๋ฐฉํ•˜๋Š” ๋ฐ ์•„์ฃผ ํšจ๊ณผ์ ์ด์—ˆ์Šต๋‹ˆ๋‹ค. ๊ฒฝ๋ฏธํ•œ ์ธ์ง€ ์žฅ์• ๊ฐ€ ์žˆ๋Š” ์‚ฌ๋žŒ์ด ์—์ด์ฝ”์‚ฌํŽœํƒ€์—”์‚ฐ ๋ฐ ๋„์ฝ”์‚ฌํ—ฅ์‚ฌ์—”์‚ฐ ์ˆ˜์น˜๊ฐ€ ๋†’์€ ๊ฒฝ์šฐ ๋น„ํƒ€๋ฏผB๊ตฐ์„ ์„ญ์ทจํ•˜๋ฉด ๋‡Œ ์œ„์ถ• ์†๋„๋ฅผ ๋‘”ํ™”์‹œํ‚ฌ ์ˆ˜ ์žˆ๋‹ค๋Š” ์ ์—์„œ ์ด๋Ÿฌํ•œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ํš๊ธฐ์ ์ธ ์„ฑ๊ณผ๋ผ๊ณ  ๋ณผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

์˜ค๋ฉ”๊ฐ€3 ์ง€๋ฐฉ์‚ฐ์„ ๋‹จ๋…์œผ๋กœ ์„ญ์ทจํ•ด๋„ ๊ธฐ๋ถ„ ๋ฐ ์ •์‹ ๊ธฐ๋Šฅ ์ ์ˆ˜๋ฅผ ๊ฐœ์„ ํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋ฉ๋‹ˆ๋‹ค. ์œ ๋ช…ํ•œ ์‹ฌ์žฅ์งˆํ™˜ ์—ฐ๊ตฌ์ธ ํ”„๋ ˆ์ด๋ฐํ–„ ์‹ฌ์žฅ ์—ฐ๊ตฌ(Framingham Heart Study)์˜ ๋ถ„์„์— ๋”ฐ๋ฅด๋ฉด ๋„์ฝ”์‚ฌํ—ฅ์‚ฌ์—”์‚ฐ ์ˆ˜์น˜๊ฐ€ ๋†’์€ ์‚ฌ๋žŒ์€ ์ˆ˜์น˜๊ฐ€ ๋‚ฎ์€ ์‚ฌ๋žŒ์— ๋น„ํ•ด ์น˜๋งค ๋ฐœ๋ณ‘๋ฅ ์ด 47% ๊ฐ์†Œํ–ˆ์Šต๋‹ˆ๋‹ค. 

์ด ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ์˜ค๋ฉ”๊ฐ€3 ์ง€๋ฐฉ์‚ฐ์ด ํ’๋ถ€ํ•œ ์ƒ์„ ์„ ์ผ์ฃผ์ผ์— 2-3ํšŒ ์„ญ์ทจํ•˜๊ฑฐ๋‚˜ ์—์ด์ฝ”์‚ฌํŽœํƒ€์—”์‚ฐ ๋ฐ ๋„์ฝ”์‚ฌํ—ฅ์‚ฌ์—”์‚ฐ 1,000mg ์ด์ƒ์ด ํ•จ์œ ๋œ ํ”ผ์‰ฌ ์˜ค์ผ์„ ๋งค์ผ ๋ณด์ถฉํ•˜๋ฉด ์‹ฌ๊ฐํ•œ ์ •์‹ ๊ธฐ๋Šฅ ์ €ํ•˜๊ฐ€ ๋ฐœ์ƒํ•  ์œ„ํ—˜์„ 50% ๊ฐ€๊นŒ์ด ์ค„์ผ ์ˆ˜ ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค.6-8 

์ข…ํ•ฉ๋น„ํƒ€๋ฏผ

๋”ฐ๋ผ์„œ ์ถฉ๋ถ„ํ•œ ๋น„ํƒ€๋ฏผB๊ตฐ๊ณผ ๋”๋ถˆ์–ด 1,000-2,000mg์˜ ์—์ด์ฝ”์‚ฌํŽœํƒ€์—”์‚ฐ ๋ฐ ๋„์ฝ”์‚ฌํ—ฅ์‚ฌ์—”์‚ฐ์„ ํ•จ์œ ํ•˜๋Š” ๊ณ ํšจ๋Šฅ ์ข…ํ•ฉ๋น„ํƒ€๋ฏผ ๋ฐ ๋ฏธ๋„ค๋ž„ ๋ณด์ถฉ์ œ๋ฅผ ์„ญ์ทจํ•˜๋ฉด ๋…ธํ™”์— ๋”ฐ๋ฅธ ์ •์‹  ์‡ ํ‡ด ์œ„ํ—˜์„ ํฌ๊ฒŒ ์ค„์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

โ€Œโ€Œโ€Œโ€Œ๊ฑด๊ฐ•์— ์ข‹์€ ์•ผ์ฑ„์™€ ๋ธ”๋ฃจ๋ฒ ๋ฆฌ

์˜ค๋ฉ”๊ฐ€3 ์ง€๋ฐฉ์‚ฐ ๊ณต๊ธ‰์›์ธ ์ƒ์„  ์™ธ์—๋„ ๋‡Œ ๊ธฐ๋Šฅ์— ๋„์›€์ด ๋˜๋Š” ์‹ํ’ˆ์€ ๋งŽ์Šต๋‹ˆ๋‹ค. 

ํ‘ธ๋ฅธ์žŽ์ฑ„์†Œ

์‹œ์นด๊ณ ์˜ ๋Ÿฌ์‹œ ๋Œ€ํ•™ ์˜๋ฃŒ์„ผํ„ฐ์—์„œ ์ง„ํ–‰ํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ๊ธฐ์–ต๋ ฅ ๋ฐ ๋…ธํ™” ํ”„๋กœ์ ํŠธ(Memory and Aging Project)์˜ ์ฐธ์—ฌ์ž 960๋ช…์„ ์กฐ์‚ฌํ–ˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ ์ฐธ์—ฌ์ž๋“ค์€ ์‹ํ’ˆ ์„ญ์ทจ ๋นˆ๋„ ์กฐ์‚ฌ์ง€๋ฅผ ์ž‘์„ฑํ•˜๊ณ  ๊ฑฐ์˜ 5๋…„ ๋™์•ˆ 2ํšŒ ์ด์ƒ ์ธ์ง€๋ ฅ ํ‰๊ฐ€๋ฅผ ๋ฐ›์•˜์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์ง„์€ ๋น„ํƒ€๋ฏผK1, ๋ฃจํ…Œ์ธ(Lutein), ์—ฝ์‚ฐ, ์•ŒํŒŒํ† ์ฝ”ํŽ˜๋กค(ฮฑ-tocopherol), ์งˆ์‚ฐ์—ผ, ์บ ํŽ˜๋กค(Kaempferol)์ด ํ’๋ถ€ํ•œ ์Œ์‹๊ณผ ํ‘ธ๋ฅธ์žŽ์ฑ„์†Œ๋ฅผ ๋งค์ผ 1ํšŒ ์ •๋„ ์„ญ์ทจํ•˜๋ฉด ๋…ธํ™”์— ๋‹ค๋ฅธ ์ธ์ง€๊ธฐ๋Šฅ ์ €ํ•˜๋ฅผ ์–ต์ œํ•  ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๊ฒฐ๋ก  ๋‚ด๋ ธ์Šต๋‹ˆ๋‹ค. 

์Šคํ”ผ๋ฃฐ๋ฆฌ๋‚˜(Spirulina)ํด๋กœ๋ ๋ผ(Chlorella)๋ฐ€์‹น ์ฆ™๋ณด๋ฆฌ์‹น ์ฆ™๊ณผ ๊ฐ™์€ ์Šˆํผํ‘ธ๋“œ๊ฐ€ ํ•จ์œ ๋œ ์•ผ์ฑ„ ๋ณด์ถฉ์ œ๋ฅผ ์‹๋‹จ์— ์ถ”๊ฐ€ํ•ด ๋ณด์‹ญ์‹œ์˜ค.

๋ธ”๋ฃจ๋ฒ ๋ฆฌ

๋ธ”๋ฃจ๋ฒ ๋ฆฌ ๋“ฑ ํ”Œ๋ผ๋ณด๋…ธ์ด๋“œ๊ฐ€ ํ’๋ถ€ํ•œ ์‹ํ’ˆ์ด๋‚˜ ์ถ”์ถœ๋ฌผ์€ ๋‡Œ ๊ธฐ๋Šฅ์„ ๋†’์ด๋Š” ๋ฐ ํŠนํžˆ ๋„์›€์ด ๋ฉ๋‹ˆ๋‹ค. ์—ฌ๋Ÿฌ ๋™๋ฌผ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋ธ”๋ฃจ๋ฒ ๋ฆฌ๋Š” ๋‡Œ์˜ ์‚ฐํ™” ์ŠคํŠธ๋ ˆ์Šค์™€ ๊ธฐ์–ต ์†์‹ค์„ ์–ต์ œํ•˜๋Š” ๋ฐ ๋„์›€์ด ๋ฉ๋‹ˆ๋‹ค.10 ์‚ฌ๋žŒ์œผ๋กœ ์น˜๋ฉด 1์ปต์— ํ•ด๋‹นํ•˜๋Š” ์–‘์˜ ๋ธ”๋ฃจ๋ฒ ๋ฆฌ๋ฅผ ๊ณ ๋ น์˜ ์ฅ์—๊ฒŒ ๋งค์ผ ํˆฌ์—ฌํ–ˆ์„ ๋•Œ ํ•™์Šต ๋Šฅ๋ ฅ๊ณผ ์šด๋™ ๋Šฅ๋ ฅ์„ ํฌ๊ฒŒ ๋†’์˜€์œผ๋ฉฐ ์–ด๋ฆฐ ์ฅ์™€ ๋Œ€๋“ฑํ•œ ์ˆ˜์ค€์œผ๋กœ ์ •์‹ ๊ธฐ๋Šฅ์„ ํ–ฅ์ƒ์‹œํ‚ฌ ์ˆ˜ ์žˆ์—ˆ์Šต๋‹ˆ๋‹ค. ์ฅ์˜ ๋‡Œ๋ฅผ ์กฐ์‚ฌํ•œ ๊ฒฐ๊ณผ ๋ธ”๋ฃจ๋ฒ ๋ฆฌ๋ฅผ ํˆฌ์—ฌํ•œ ์ฅ์˜ ๋‡Œ์„ธํฌ๋Š” ๊ทธ๋ ‡์ง€ ์•Š์€ ๋‹ค๋ฅธ ๋‚˜์ด ๋“  ์ฅ๋ณด๋‹ค ๋” ํšจ๊ณผ์ ์œผ๋กœ ์˜์‚ฌ์†Œํ†ต์„ ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. 

๋ธ”๋ฃจ๋ฒ ๋ฆฌ ์„ญ์ทจ๋ฅผ ๋Š˜๋ฆฌ๋ฉด์„œ ํ”Œ๋ผ๋ณด๋…ธ์ด๋“œ๊ฐ€ ํ’๋ถ€ํ•œ ๋ธ”๋ฃจ๋ฒ ๋ฆฌํฌ๋„์”จ, ์†Œ๋‚˜๋ฌด ๊ป์งˆ ๋“ฑ์˜ ์ถ”์ถœ๋ฌผ 100-300mg์„ ๋งค์ผ ๋ณด์ถฉํ•˜์‹ญ์‹œ์˜ค.

โ€Œโ€Œโ€Œโ€Œ๋‡Œ ๊ฑด๊ฐ•์— ์ข‹์€ ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ(Pyrroloquinoline quinone, PQQ), ์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด(Acetyl-L-carnitine), ๋ ˆ์Šค๋ฒ ๋ผํŠธ๋กค(Resveratrol), ์ปคํ๋ฏผ(Curcumin)

๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„๋Š” ์„ธํฌ ๋‚ด์—์„œ ์—๋„ˆ์ง€๋ฅผ ์ƒ์„ฑํ•˜๋Š” ์„ธํฌ์†Œ๊ธฐ๊ด€์ž…๋‹ˆ๋‹ค. ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„์˜ ๊ธฐ๋Šฅ ์ €ํ•˜๊ฐ€ ๋…ธํ™”, ์ธ์ง€๊ธฐ๋Šฅ ์ €ํ•˜, ๊ธฐ์–ต๋ ฅ ๊ฐํ‡ด์™€ ๊ฐ™์€ ์ฆ์ƒ์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์„ ๋ฐํžŒ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๊ฐ€ ๋Š˜์–ด๋‚˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์‚ฌ๋žŒ์˜ ๋‡Œ๋Š” ๋ชธ๋ฌด๊ฒŒ์˜ 2% ์ •๋„์— ๋ถˆ๊ณผํ•˜์ง€๋งŒ ์ฒด๋‚ด ์—๋„ˆ์ง€์™€ ์‚ฐ์†Œ์˜ 20% ์ด์ƒ์„ ์†Œ๋น„ํ•ฉ๋‹ˆ๋‹ค. ๋‡Œ๊ฐ€ ๊ฑด๊ฐ•ํ•˜๊ฒŒ ๊ธฐ๋Šฅํ•˜๋ ค๋ฉด ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„์—์„œ ์—๋„ˆ์ง€๋ฅผ ์›ํ™œํ•˜๊ฒŒ ์ƒ์‚ฐํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค. 

๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ๊ธฐ๋Šฅ์„ ์ฆ์ง„ํ•˜๋ ค๋ฉด ๋‹ค์Œ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.

์ฝ”ํํ…๊ณผ ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ

๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ๊ธฐ๋Šฅ์„ ์ฆ์ง„ํ•˜๋Š” ์ฝ”ํํ… ๋ฐ ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ์€ ํ•จ๊ป˜ ์ž‘์šฉํ•˜์—ฌ ๊ธฐ์–ต๋ ฅ๊ณผ ์ธ์ง€๋ ฅ์„ ํšจ๊ณผ์ ์œผ๋กœ ๊ฐœ์„ ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค. 

์ด๋ฏธ ์ž˜ ์•Œ๋ ค์ ธ ์žˆ๋Š” ์ฝ”ํํ…๊ณผ๋Š” ๋‹ฌ๋ฆฌ ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ์€ ์ด์ œ ๋Œ€์ค‘ํ™”๋˜๊ธฐ ์‹œ์ž‘ํ•œ ์˜์–‘์†Œ์ž…๋‹ˆ๋‹ค. ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ์€ ํŠนํžˆ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„๊ฐ€ ์†์ƒ๋˜์ง€ ์•Š๋„๋ก ๋ณดํ˜ธํ•˜๋Š” ๊ฐ•๋ ฅํ•œ ํ•ญ์‚ฐํ™”์ œ์ž…๋‹ˆ๋‹ค. ๋˜ํ•œ ๋…ธํ™” ์„ธํฌ ๋‚ด์—์„œ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ์‹ ์ƒ(Mitochondrial biogenesis), ์ฆ‰ ์ƒˆ๋กœ์šด ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„์˜ ์ž๋ฐœ์ ์ธ ์ƒ์„ฑ์„ ์ด‰์ง„ํ•ฉ๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ํšจ๋Šฅ์€ ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ์ด ํ•ญ๋…ธํ™” ์„ฑ๋ถ„์œผ๋กœ ์ฃผ๋ชฉ๋ฐ›๋Š” ์ด์œ ์ž…๋‹ˆ๋‹ค.

ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ์€ ๋…์ž์ ์œผ๋กœ๋„ ํšจ๊ณผ์ ์ด์ง€๋งŒ ์ฝ”ํํ…๊ณผ ๋ณ‘์šฉํ•˜๋ฉด ๋” ๋›ฐ์–ด๋‚œ ํšจ๊ณผ๋ฅผ ๋ณด์ด๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค. 40-70์„ธ์˜ ์„ฑ์ธ 71๋ช…์„ ๋Œ€์ƒ์œผ๋กœ ํ•œ ์—ฐ๊ตฌ์—์„œ ๋งค์ผ ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ 20mg์„ ๋ณด์ถฉํ•œ ๊ทธ๋ฃน์€ ์œ„์•ฝ ๊ทธ๋ฃน์— ๋น„ํ•ด ๊ณ ๋“ฑ ์ธ์ง€๊ธฐ๋Šฅ์ด ํ–ฅ์ƒ๋˜์—ˆ์œผ๋ฉฐ ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ 20mg๊ณผ ์ฝ”ํํ… 300mg์„ ๋ณ‘์šฉํ•œ ๊ทธ๋ฃน์€ ๋”์šฑ ํฐ ๊ฐœ์„  ํšจ๊ณผ๋ฅผ ๋ณผ ์ˆ˜ ์žˆ์—ˆ์Šต๋‹ˆ๋‹ค.11 ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ๊ณผ ์ฝ”ํํ…์ด ๋ชจ๋‘ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ์—๋„ˆ์ง€ ์ƒ์„ฑ์— ๊ด€์—ฌํ•œ๋‹ค๋Š” ์‚ฌ์‹ค์„ ๊ณ ๋ คํ•˜๋ฉด ์ด๋Ÿฌํ•œ ๊ฒฐ๊ณผ๋Š” ๋‹น์—ฐํ•œ ๊ฒƒ์ผ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.11,12 

์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด

์นด๋ฅด๋‹ˆํ‹ด์˜ ๊ฐ€์žฅ ์ค‘์š”ํ•œ ํ˜•ํƒœ์ธ ์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด(Acetyl-L-carnitine, ALC)์€ ์ฒด๋‚ด์—์„œ ์ƒ์„ฑ๋˜์ง€๋งŒ ๊ฐ€๋” ๊ฒฐํ•๋˜๋Š” ๊ฒฝ์šฐ๋„ ์žˆ์Šต๋‹ˆ๋‹ค. 

์นด๋ฅด๋‹ˆํ‹ด(Carnitine)์€ ์ง€๋ฐฉ, ํƒ„์ˆ˜ํ™”๋ฌผ, ๋‹จ๋ฐฑ์งˆ ๋Œ€์‚ฌ ๋ฐ ์—๋„ˆ์ง€ ์ƒ์‚ฐ์— ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•˜๋ฉฐ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ๋Œ€์‚ฌ์— ํ•„์ˆ˜์ ์ž…๋‹ˆ๋‹ค. ์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด์€ ํŠนํžˆ ๋‡Œ ๊ฑด๊ฐ•์— ์ข‹์€ ์นด๋ฅด๋‹ˆํ‹ด ํ˜•ํƒœ๋กœ ์—ฌ๊ฒจ์ง‘๋‹ˆ๋‹ค.13 

์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด์€ ๋‡Œ์„ธํฌ ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„์˜ ํ™œ๋™์„ ๋ณดํ˜ธ ๋ฐ ์ด‰์ง„ํ•˜๋ฉฐ ์‚ฐํ™” ์ŠคํŠธ๋ ˆ์Šค๋ฅผ ์ค„์ž„์œผ๋กœ์จ ๋‡Œ์„ธํฌ ๋‚ด์—์„œ ์—๋„ˆ์ง€ ์ƒ์„ฑ์„ ๋Š˜๋ฆฌ๊ณ  ๋‡Œ ๊ธฐ๋Šฅ์„ ์ฆ์ง„ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

์ž„์ƒ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด์€ ์ •์‹ ๊ธฐ๋Šฅ๊ณผ ๊ธฐ์–ต๋ ฅ์„ ํ–ฅ์ƒ์‹œํ‚ฌ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋‹จ๊ธฐ ํ•™์Šต ๊ณผ์ œ, ํŠน์ˆ˜ ํ•™์Šต ๊ณผ์ œ, ํ•œ์ •๋œ ์‹œ๊ฐ„ ๋™์•ˆ์˜ ์ฃผ์˜๋ ฅ ๊ณผ์ œ, ๊ฐœ์ธ ์ธ์‹ ๊ณผ์ œ๋ฅผ ์ˆ˜ํ–‰ํ•˜๋Š” ๋Šฅ๋ ฅ์ด ์ผ๋ถ€ ๊ฐœ์„ ๋œ ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค. ์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด์€ ์„ญ์ทจํ•œ ์ง€ ํ•œ ๋‹ฌ ์ด๋‚ด์— ํšจ๊ณผ๋ฅผ ๋‚˜ํƒ€๋‚ด๋Š” ๊ฒฝ์šฐ๋„ ๊ฐ„ํ˜น ์žˆ์ง€๋งŒ ์žฅ๊ธฐ๊ฐ„(์˜ˆ: 1๋…„ ์ด์ƒ) ์‚ฌ์šฉํ•˜๋ฉด ์žฅ๊ธฐ ๊ธฐ์–ต ๋ฐ ์ฃผ์˜๋ ฅ์„ ํ™•์‹คํžˆ ํ–ฅ์ƒ์‹œํ‚ฌ ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.14 ์ผ๋ฐ˜์ ์œผ๋กœ ์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด์˜ ํ•˜๋ฃจ ๊ถŒ์žฅ์„ญ์ทจ๋Ÿ‰์€ 900-1,500mg์ž…๋‹ˆ๋‹ค.

๋ ˆ์Šค๋ฒ ๋ผํŠธ๋กค 

๋ ˆ์Šค๋ฒ ๋ผํŠธ๋กค์€ ์ ํฌ๋„ ๊ป์งˆ, ๋ ˆ๋“œ์™€์ธ, ์ฝ”์ฝ”์•„ ๋ถ„๋ง, ๋ฒ ์ดํ‚น ์ดˆ์ฝœ๋ฆฟ, ๋‹คํฌ ์ดˆ์ฝœ๋ฆฟ, ๋•…์ฝฉ, ๋ฝ•๋‚˜๋ฌด ๊ป์งˆ์— ๋‚ฎ์€ ์ˆ˜์ค€์œผ๋กœ ํ•จ์œ ๋œ ์‹๋ฌผ์„ฑ ํ™”ํ•ฉ๋ฌผ์ž…๋‹ˆ๋‹ค. ๋ ˆ์Šค๋ฒ ๋ผํŠธ๋กค์€ ์„ธํฌ ์ˆ˜๋ช… ์กฐ์ ˆ์— ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•˜๋Š” ํšจ์†Œ์ธ ์‹œ๋ฅดํˆฌ์ธ1(Sirtuin 1)์„ ํ™œ์„ฑํ™”ํ•˜๋ฉฐ ์ธ์Š๋ฆฐ ํ™œ์„ฑ์„ ๋†’์—ฌ ๋‡Œ ๊ธฐ๋Šฅ์„ ์ฆ์ง„ํ•˜๊ณ  ํ˜ˆ๋‹น ์กฐ์ ˆ ๊ธฐ๋Šฅ์„ ๊ฐœ์„ ํ•ฉ๋‹ˆ๋‹ค.

์ž„์ƒ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๋ ˆ์Šค๋ฒ ๋ผํŠธ๋กค์€ ๋…ธ์ธ์˜ ๋…ธํ™” ๋ฐ ์ •์‹ ๊ธฐ๋Šฅ ์ €ํ•˜์™€ ๊ด€๋ จ๋œ ๋‡Œ ์—ผ์ฆ ์ง€ํ‘œ๋ฅผ ๋‚ฎ์ถฅ๋‹ˆ๋‹ค.15,16 ๊ทธ ๊ฒฐ๊ณผ ๋ ˆ์Šค๋ฒ ๋ผํŠธ๋กค์€ ๋…ธ์ธ์˜ ๊ธฐ๋ถ„, ์ธ์ง€๋ ฅ, ์ผ์ƒ์ƒํ™œ ํ™œ๋™ ์ธก์ •์น˜๋ฅผ ๊ฐœ์„ ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.

๋Œ€๋ถ€๋ถ„์˜ ๋ ˆ์Šค๋ฒ ๋ผํŠธ๋กค ๋ณด์ถฉ์ œ๋Š” ํด๋ฆฌ๊ณ ๋ˆ” ์ฟ ์Šคํ”ผ๋‹คํˆผ(Polygonum cuspidatum)์œผ๋กœ๋„ ๋ถˆ๋ฆฌ๋Š” ํ˜ธ์žฅ๊ทผ(Japanese knotweed)์œผ๋กœ ๋งŒ๋“ญ๋‹ˆ๋‹ค. ์ผ๋ฐ˜์ ์œผ๋กœ ์ฒœ์—ฐ ํŠธ๋žœ์Šค ๋ ˆ์Šค๋ฒ ๋ผํŠธ๋กค(Trans-resveratrol)์˜ ํ•˜๋ฃจ ๊ถŒ์žฅ์„ญ์ทจ๋Ÿ‰์€ 1,000mg์ž…๋‹ˆ๋‹ค. 

์ปคํ๋ฏผ

์ปคํ๋ฏผ(Curcumin)์€ ๊ฐ•ํ™ฉ์˜ ๋…ธ๋ž€์ƒ‰์„ ๋‚ด๋Š” ์ƒ‰์†Œ์ž…๋‹ˆ๋‹ค. ๋‹ค์–‘ํ•œ ํ•ญ๋…ธํ™” ํšจ๋Šฅ์ด ์žˆ๋Š” ์ปคํ๋ฏผ์€ ๋‡Œ ๋ณดํ˜ธ์ œ ๋ฐ ๋‡Œ ๊ธฐ๋Šฅ ์ฆ์ง„์ œ๋กœ์„œ๋„ ๋†€๋ผ์šด ๊ฐ€๋Šฅ์„ฑ์„ ๋ณด์—ฌ์ค๋‹ˆ๋‹ค.17 

๊ฐ•ํ™ฉ ์†Œ๋น„๋Ÿ‰์ด ๋งŽ์€ ์ธ๋„ ์‹œ๊ณจ ์ง€์—ญ์€ ๋…ธ์ธ์„ฑ ๋‡Œ ์งˆํ™˜ ๋ฐœ์ƒ๋ฅ ์ด ์ „ ์„ธ๊ณ„์—์„œ ๊ฐ€์žฅ ๋‚ฎ์€ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ์‹์‚ฌ๋ฅผ ํ†ตํ•ด์„œ๋„ ์นด๋ ˆ์˜ ์ฃผ์„ฑ๋ถ„์ธ ๊ฐ•ํ™ฉ์„ ์ถฉ๋ถ„ํžˆ ์„ญ์ทจํ•  ์ˆ˜ ์žˆ์ง€๋งŒ ์ปคํ๋ฏผ ๋ณด์ถฉ์ œ๋ฅผ ์‚ฌ์šฉํ•˜๋ฉด ์„ญ์ทจ๋Ÿ‰์„ ๋Š˜๋ ค ๋” ์ข‹์€ ํšจ๊ณผ๋ฅผ ์–ป์„ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

UC ๋กœ์Šค์•ค์ ค๋ ˆ์Šค์—์„œ ์ˆ˜ํ–‰ํ•œ ์—ฐ๊ตฌ์—์„œ๋Š” ์ธ์ง€ ๋ฐ ๊ธฐ์–ต๋ ฅ ์žฅ์• ๊ฐ€ ์žˆ๋Š” 50-90์„ธ์˜ ์„ฑ์ธ 40๋ช…์—๊ฒŒ 18๊ฐœ์›”๊ฐ„ ํ•˜๋ฃจ 2ํšŒ ํ…Œ๋ผํ๋ฏผ(Theracurmin) 90mg ๋˜๋Š” ์œ„์•ฝ์„ ๋ฌด์ž‘์œ„๋กœ ํˆฌ์—ฌํ–ˆ์Šต๋‹ˆ๋‹ค. ํ…Œ๋ผํ๋ฏผ์€ ์ƒ์ฒด์ด์šฉ๋ฅ ์ด ๋†’์€ ์ปคํ๋ฏผ์˜ ํ•œ ํ˜•ํƒœ์ž…๋‹ˆ๋‹ค.18 

40๋ช…์˜ ํ”ผํ—˜์ž๋“ค์€ ๋ชจ๋‘ ์—ฐ๊ตฌ๋ฅผ ์‹œ์ž‘ํ•  ๋•Œ ํ‘œ์ค€ํ™”๋œ ์ข…ํ•ฉ ์ •์‹  ํ‰๊ฐ€๋ฅผ ๋ฐ›์€ ํ›„ 18๊ฐœ์›”์ด ์ง€๋‚  ๋•Œ๊นŒ์ง€ 6๊ฐœ์›”๋งˆ๋‹ค ๋‹ค์‹œ ํ‰๊ฐ€๋ฐ›์•˜์Šต๋‹ˆ๋‹ค. ๊ทธ ๊ฒฐ๊ณผ ํ…Œ๋ผํ๋ฏผ์€ ๊ธฐ์–ต๋ ฅ๊ณผ ์ฃผ์˜๋ ฅ์„ ํฌ๊ฒŒ ํ–ฅ์ƒ์‹œ์ผฐ์ง€๋งŒ ์œ„์•ฝ์€ ๊ทธ๋ ‡์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค. ๊ธฐ์–ต๋ ฅ ํ‰๊ฐ€์—์„œ ์ปคํ๋ฏผ์„ ์„ญ์ทจํ•œ ์‚ฌ๋žŒ์€ ๊ธฐ์–ต๋ ฅ์ด 18๊ฐœ์›” ๋™์•ˆ 28% ํ–ฅ์ƒ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ์ปคํ๋ฏผ ๊ทธ๋ฃน์€ ์•ฝ๊ฐ„์˜ ๊ธฐ๋ถ„ ๊ฐœ์„  ํšจ๊ณผ๋„ ๊ฒฝํ—˜ํ–ˆ์œผ๋ฉฐ ๋‡Œ ์–‘์ „์ž๋ฐฉ์ถœ๋‹จ์ธต์ดฌ์˜(PET) ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ๋‡Œ ์†์ƒ๋„ ํ›จ์”ฌ ์ ์€ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋กœ ๋ณผ ๋•Œ ๋…ธํ™”์— ๋”ฐ๋ฅธ ์ •์‹ ๊ธฐ๋Šฅ ํ‡ดํ™”๋ฅผ ์˜ˆ๋ฐฉํ•˜๋ ค๋ฉด ํ…Œ๋ผํ๋ฏผ๊ณผ ๊ธฐํƒ€ ์ปคํ๋ฏผ ๋ณด์ถฉ์ œ๋ฅผ ์„ญ์ทจํ•˜๋Š” ๊ฒƒ์ด ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค.

โ€Œโ€Œโ€Œโ€Œ๋…ธํ™”๋ฅผ ํšจ๊ณผ์ ์œผ๋กœ ์–ต์ œํ•˜๋Š” ๊ธ€๋ฃจํƒ€์น˜์˜จ 

๊ธ€๋ฃจํƒ€์น˜์˜จ์€ ๋ชจ๋“  ์ฒด๋‚ด ์„ธํฌ์—์„œ ์ƒ์„ฑ๋˜๋Š” ์ค‘์š”ํ•œ ๋ฌผ์งˆ์ž…๋‹ˆ๋‹ค.  ๊ธ€๋ฃจํƒ€์น˜์˜จ์€ ์„ธํฌ๊ฐ€ ์†์ƒ๋˜์ง€ ์•Š๋„๋ก ๋ณดํ˜ธํ•  ๋ฟ ์•„๋‹ˆ๋ผ ์œ ํ•ด๋ฌผ์งˆ์„ ์ œ๊ฑฐํ•˜๋Š” ๋ฐ๋„ ๋„์›€์ด ๋ฉ๋‹ˆ๋‹ค. 

๊ธ€๋ฃจํƒ€์น˜์˜จ์€ ๊ธ€๋ฃจํƒ€๋ฉ”์ดํŠธ(Glutamate), ์‹œ์Šคํ…Œ์ธ(Cysteine), ๊ธ€๋ฆฌ์‹ (Glycine) ๋“ฑ์˜ ์•„๋ฏธ๋…ธ์‚ฐ์œผ๋กœ ๊ตฌ์„ฑ๋œ ์ž‘์€ ๋‹จ๋ฐฑ์งˆ์ž…๋‹ˆ๋‹ค.  ์ง€๋‚œ 100๋…„๊ฐ„ ๋ฐœํ‘œ๋œ 10๋งŒ ๊ฑด ์ด์ƒ์˜ ๋…ผ๋ฌธ์— ๋”ฐ๋ฅด๋ฉด ์„ธํฌ ๋‚ด ๊ธ€๋ฃจํƒ€์น˜์˜จ ์ˆ˜์น˜๋ฅผ ๊ฑด๊ฐ•ํ•œ ์ˆ˜์ค€์œผ๋กœ ์œ ์ง€ํ•˜๋ฉด ์„ธํฌ ๊ธฐ๋Šฅ๊ณผ ๋ฉด์—ญ๊ณ„ ๊ฑด๊ฐ•์„ ์ง€ํ‚ค๊ณ  ๋…ธํ™”๋ฅผ ์ง€์—ฐํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๊ธ€๋ฃจํƒ€์น˜์˜จ์€ ์ฒด๋‚ด์—์„œ ๊ฐ€์žฅ ํšจ๊ณผ์ ์ธ ํ•ด๋…์ œ์ž…๋‹ˆ๋‹ค. ๊ธ€๋ฃจํƒ€์น˜์˜จ์€ ํ•ด๋กœ์šด ๋…์†Œ, ์˜ค์—ผ ๋ฌผ์งˆ, ํ™”ํ•™ ๋ฌผ์งˆ, ์ค‘๊ธˆ์†, ์•ฝ๋ฌผ ๋Œ€์‚ฌ ์‚ฐ๋ฌผ๊ณผ ๊ฒฐํ•ฉํ•˜์—ฌ ์†Œ๋ณ€์ด๋‚˜ ์žฅ์„ ํ†ตํ•ด ์ด๋“ค์„ ๋ฐฐ์ถœ์‹œํ‚ต๋‹ˆ๋‹ค.19

๋‚˜์ด๊ฐ€ ๋“ค์ˆ˜๋ก, ๋˜๋Š” ๋…์†Œ, ์•ฝ์ œ, ํ™˜๊ฒฝ ์˜ค์—ผ, ์‚ฐํ™”์  ์†์ƒ ์œ ๋ฐœ ๋ฌผ์งˆ์— ๋งŽ์ด ๋…ธ์ถœ๋ ์ˆ˜๋ก ๊ธ€๋ฃจํƒ€์น˜์˜จ ์ˆ˜์น˜๋Š” ๋‚ฎ์•„์ง€๊ธฐ ์‰ฝ์Šต๋‹ˆ๋‹ค. ๋‡Œ๋‚ด ๊ธ€๋ฃจํƒ€์น˜์˜จ์ด ๊ฐ์†Œํ•˜๋ฉด ๋‡Œ์„ธํฌ์— ์น˜๋ช…์ ์ž…๋‹ˆ๋‹ค.20 ๊ธ€๋ฃจํƒ€์น˜์˜จ ์ˆ˜์น˜๋ฅผ ๋†’์ด๋Š” ๋ฐ๋Š” ๊ฑด๊ฐ•ํ•œ ์‹๋‹จ๋„ ์–ด๋Š ์ •๋„ ๋„์›€์ด ๋  ์ˆ˜ ์žˆ์ง€๋งŒ ๋ณด์ถฉ์ œ๊ฐ€ ํ›จ์”ฌ ๋” ํšจ๊ณผ์ ์ž…๋‹ˆ๋‹ค. 

๊ธ€๋ฃจํƒ€์น˜์˜จ ์ˆ˜์น˜๋ฅผ ๋†’์ด๋ ค ํ•  ๋•Œ ์ผ๋ฐ˜์ ์œผ๋กœ ์‚ฌ์šฉํ•˜๋Š” ๋ณด์ถฉ์ œ๋กœ๋Š” ๊ธ€๋ฃจํƒ€์น˜์˜จ๊ณผ ์•„์„ธํ‹ธ์‹œ์Šคํ…Œ์ธ(N-acetylcysteine, NAC)์ด ์žˆ์Šต๋‹ˆ๋‹ค. ์ตœ๊ทผ์˜ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์˜ค๊ธฐ ์ „๊นŒ์ง€๋งŒ ํ•ด๋„ ๊ฒฝ๊ตฌ๋กœ ์„ญ์ทจํ•  ๋•Œ ํก์ˆ˜๊ฐ€ ์•ˆ ๋  ์ˆ˜ ์žˆ๋‹ค๋Š” ์ด์œ ๋กœ ๊ธ€๋ฃจํƒ€์น˜์˜จ์ด ๋ณด์ถฉ์ œ๋กœ ์ ํ•ฉํ•œ์ง€์— ๋Œ€ํ•ด ์•ฝ๊ฐ„์˜ ๋…ผ๋ž€์ด ์žˆ์—ˆ์Šต๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ์—ฌ๋Ÿฌ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ๊ฒฝ๊ตฌ๋กœ ์„ญ์ทจํ•œ ๊ธ€๋ฃจํƒ€์น˜์˜จ์€ ํก์ˆ˜๊ฐ€ ์ด๋ฃจ์–ด์ง„ ํ›„ ์‹ ์ฒด์˜ ์„ธํฌ ๋ณดํ˜ธ ๋Šฅ๋ ฅ์„ ๋†’์ด๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค.21 

์ผ๋ฐ˜์ ์œผ๋กœ ํ™˜์›ํ˜• ๊ธ€๋ฃจํƒ€์น˜์˜จ์˜ ํ•˜๋ฃจ ๊ถŒ์žฅ ์„ญ์ทจ๋Ÿ‰์€ 250-1,000mg์ž…๋‹ˆ๋‹ค. ๋‡Œ๋‚ด ์ˆ˜์น˜๋ฅผ ํฌํ•จํ•˜์—ฌ ๊ธ€๋ฃจํƒ€์น˜์˜จ์˜ ์กฐ์ง ๋‚ด ์ˆ˜์ค€์„ ๋†’์ด๋ ค๋ฉด ์ผ๋ฐ˜์ ์œผ๋กœ ๋งค์ผ 500-1,200mg์˜ ์•„์„ธํ‹ธ์‹œ์Šคํ…Œ์ธ์„ ์„ญ์ทจํ•˜๋Š” ๊ฒƒ์ด ์ข‹์Šต๋‹ˆ๋‹ค.22 

โ€Œโ€Œโ€Œโ€Œ๋‡Œ ๋ณดํ˜ธ์— ํšจ๊ณผ์ ์ธ L-์„ธ๋ฆฐ 

ํด ์ฝ•์Šค(Paul Cox)๋Š” ํ‡ดํ–‰์„ฑ ๋‡Œ ์งˆํ™˜์˜ ์ง„ํ–‰์„ ๋ฉˆ์ถ”๊ฑฐ๋‚˜ ๋Šฆ์ถ”๊ฑฐ๋‚˜ ์—ญ์ „์‹œํ‚ฌ ์ˆ˜ ์žˆ๋Š” ์ด๋ก ์„ ์ฒ˜์Œ์œผ๋กœ ์ œ๊ธฐํ•œ ๋ฏผ์† ์‹๋ฌผํ•™์ž์ž…๋‹ˆ๋‹ค. ๋ฏผ์† ์‹๋ฌผํ•™(Ethnobotany)์ด๋ž€ ์›์ฃผ๋ฏผ์ด ์ „ํ†ต ๊ด€์Šต๊ณผ ์‹๋‹จ์— ์‹๋ฌผ์„ ์ด์šฉํ•˜๋Š” ๋ฐฉ์‹์„ ์—ฐ๊ตฌํ•˜๋Š” ํ•™๋ฌธ์ž…๋‹ˆ๋‹ค. 

1990๋…„ ํ›„๋ฐ˜๊ธฐ์— ํ•˜๋ฒ„๋“œ ๋Œ€ํ•™๊ต ์ถœ์‹ ์˜ ์ฝ•์Šค(Cox) ๋ฐ•์‚ฌ๋Š” ๊ดŒ ์ฐจ๋ชจ๋กœ(Chamorro) ์ง€์—ญ์˜ ์›์ฃผ๋ฏผ์ด ์–ธ์–ด ์žฅ์• , ์•ˆ๋ฉด ๋งˆ๋น„, ์šด๋™ ๋Šฅ๋ ฅ ์ƒ์‹ค, ์ด๋™์„ฑ ์ƒ์‹ค, ์น˜๋งค์™€ ๊ฐ™์€ ํ‡ดํ–‰์„ฑ ๋‡Œ ์งˆํ™˜์˜ ์ฆ์ƒ์„ ๋‚˜ํƒ€๋‚ด๋Š” ํ™•๋ฅ ์ด ๋‹ค๋ฅธ ์ง€์—ญ ์‚ฌ๋žŒ์— ๋น„ํ•ด 100๋ฐฐ ์ด์ƒ ๋†’์€ ์ด์œ ๋ฅผ ์ฐพ๊ณ ์ž ํ–ˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์ฆ์ƒ๊ณผ ๊ด€๋ จ๋œ ํ‡ดํ–‰์„ฑ ๋‡Œ ์งˆํ™˜์—๋Š” ๋ฃจ๊ฒŒ๋ฆญ๋ณ‘(๊ทผ์œ„์ถ•์„ฑ ์ธก์‚ญ๊ฒฝํ™”์ฆ, ALS, Amyotrophic lateral sclerosis), ์•Œ์ธ ํ•˜์ด๋จธ๋ณ‘, ํŒŒํ‚จ์Šจ๋ณ‘ ๋“ฑ์ด ์žˆ์Šต๋‹ˆ๋‹ค.

2002๋…„ ์ฝ•์Šค ๋ฐ•์‚ฌ๋Š” ์ตœ๊ทผ ์ž‘๊ณ ํ•œ ์‹ ๊ฒฝํ•™์ž ์˜ฌ๋ฆฌ๋ฒ„ ์‚ญ์Šค(Oliver Sacks)์™€ ํ•จ๊ป˜ ์‹ ๊ฒฝํ•™ ํ•™์ˆ ์ง€ ๋‰ด๋กค๋กœ์ง€(Neurology)์— ๋ฐœํ‘œํ•œ ๋…ผ๋ฌธ์—์„œ ์ž์‹ ์ด ์ฐพ์€ ํ•ด๋‹ต์„ ๊ณต๊ฐœํ–ˆ์Šต๋‹ˆ๋‹ค. ๊ทธ๋Š” ์ฐจ๋ชจ๋กœ ์›์ฃผ๋ฏผ์˜ ์ฃผ์‹์— ๋…์„ฑ ํ™”ํ•ฉ๋ฌผ์ธ ๋ฒ ํƒ€-๋ฉ”ํ‹ธ์•„๋ฏธ๋…ธ-L-์•Œ๋ผ๋‹Œ(ฮฒ-methylamino-L-alanine, BMAA) ํ•จ๋Ÿ‰์ด ๊ทน๋„๋กœ ๋†’์œผ๋ฉฐ ์ด๋Š” ๋‡Œ ํ‡ดํ–‰์˜ ์›์ธ์ด ๋œ๋‹ค๋Š” ๊ฐ€์„ค์„ ์ œ๊ธฐํ–ˆ์Šต๋‹ˆ๋‹ค. ๋ฏธ๊ตญ, ํ”„๋ž‘์Šค ๋“ฑ ๋‹ค๋ฅธ ์ง€์—ญ์˜ ํ˜„์ง€์ธ๋“ค์„ ๋Œ€์ƒ์œผ๋กœ ํ•œ ์—ฐ๊ตฌ์—์„œ๋„ ๋ฒ ํƒ€-๋ฉ”ํ‹ธ์•„๋ฏธ๋…ธ-L-์•Œ๋ผ๋‹Œ ํ•จ๋Ÿ‰์ด ๋†’์€ ์‹ํ’ˆ์„ ๋งŽ์ด ์„ญ์ทจํ• ์ˆ˜๋ก ๋‡Œ ํ‡ดํ–‰์ด ๋ฐœ์ƒํ•  ๊ฐ€๋Šฅ์„ฑ์ด ๋†’์•„์ง€๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค.  

๋ฒ ํƒ€-๋ฉ”ํ‹ธ์•„๋ฏธ๋…ธ-L-์•Œ๋ผ๋‹Œ์€ ์•„๋ฏธ๋…ธ์‚ฐ์ธ L-์„ธ๋ฆฐ์„ ๋Œ€์ฒดํ•˜์—ฌ ๋‡Œ ๋‹จ๋ฐฑ์งˆ ํ˜•ํƒœ๋ฅผ ๋ณ€ํ˜•ํ•จ์œผ๋กœ์จ ๋‡Œ๋ฅผ ์†์ƒ์‹œํ‚ต๋‹ˆ๋‹ค. ๊ตฌ์ฒด์ ์œผ๋กœ ์„ค๋ช…ํ•˜๋ฉด ๋‡Œ์„ธํฌ๋Š” ๋‹จ๋ฐฑ์งˆ์„ ์ƒ์„ฑํ•˜๋Š” ๊ณผ์ •์—์„œ ๋ฒ ํƒ€-๋ฉ”ํ‹ธ์•„๋ฏธ๋…ธ-L-์•Œ๋ผ๋‹Œ์„ L-์„ธ๋ฆฐ์œผ๋กœ ์ฐฉ๊ฐํ•ด L-์„ธ๋ฆฐ ๋Œ€์‹ ์— ๋ฒ ํƒ€-๋ฉ”ํ‹ธ์•„๋ฏธ๋…ธ-L-์•Œ๋ผ๋‹Œ์„ ์‚ฌ์šฉํ•ด ๋น„์ •์ƒ์ ์ธ ํ˜•ํƒœ์˜ ๋‹จ๋ฐฑ์งˆ์„ ๋งŒ๋“ค๊ฒŒ ๋ฉ๋‹ˆ๋‹ค. ์ด์™€ ๊ฐ™์ด ์ƒ์„ฑ๋œ ๋ณ€์„ฑ ๋‹จ๋ฐฑ์งˆ์€ ๋‡Œ์„ธํฌ์— ๋…์„ฑ์„ ๋‚˜ํƒ€๋ƒ…๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ๋‹จ๋ฐฑ์งˆ์€ ์ด์ƒํ•œ ๋ฐฉ์‹์œผ๋กœ ์ ‘ํžˆ๊ฑฐ๋‚˜ ์•„์˜ˆ ์ ‘ํžˆ์ง€ ์•Š๋Š” ๋“ฑ ๋‹จ๋ฐฑ์งˆ ๊ณ ์œ ์˜ ์ ‘ํžŒ ๊ตฌ์กฐ๋ฅผ ํ˜•์„ฑํ•˜์ง€ ๋ชปํ•ฉ๋‹ˆ๋‹ค. 

๋˜ํ•œ ๋ฒ ํƒ€-๋ฉ”ํ‹ธ์•„๋ฏธ๋…ธ-L-์•Œ๋ผ๋‹Œ์€ ๋‡Œ์—์„œ ๋ฒ ํƒ€-์นด๋ณด๋„ค์ดํŠธ(Beta-carbonate)๋ผ๋Š” ๋…์†Œ๋ฅผ ํ˜•์„ฑํ•  ์ˆ˜๋„ ์žˆ์Šต๋‹ˆ๋‹ค. ์ด ๋ฌผ์งˆ์€ ์‹ ๊ฒฝ์ „๋‹ฌ๋ฌผ์งˆ์ธ N-๋ฉ”ํ‹ธ-D-์•„์ŠคํŒŒ๋ฅดํ…Œ์ดํŠธ(N-methyl-D-aspartate, NMDA)์— ๋Œ€ํ•œ ๋‡Œ์„ธํฌ ์ˆ˜์šฉ์ฒด์— ๊ฒฐํ•ฉํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋ฒ ํƒ€-์นด๋ณด๋„ค์ดํŠธ๊ฐ€ ์ด ์ˆ˜์šฉ์ฒด์— ๊ฒฐํ•ฉํ•˜๋ฉด ๋‹ค์–‘ํ•œ ๊ฒฝ๋กœ๋กœ ๋‡Œ์„ธํฌ๋ฅผ ์†์ƒ์‹œ์ผœ ์„ธํฌ ์‚ฌ๋ฉธ์„ ์ดˆ๋ž˜ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

์ž„์ƒ์ „ ์‹œํ—˜์— ๋”ฐ๋ฅด๋ฉด ๋ฒ ํƒ€-๋ฉ”ํ‹ธ์•„๋ฏธ๋…ธ-L-์•Œ๋ผ๋‹Œ์— ๋…ธ์ถœํ•œ ๋‡Œ์„ธํฌ๋ฅผ L-์„ธ๋ฆฐ์œผ๋กœ ์ฒ˜๋ฆฌํ•˜๋ฉด ์ž˜๋ชป ์ ‘ํžˆ๊ฑฐ๋‚˜ ์ ‘ํžˆ์ง€ ์•Š์€ ๋‹จ๋ฐฑ์งˆ์˜ ํ˜•์„ฑ์„ ์–ต์ œํ•  ์ˆ˜ ์žˆ์—ˆ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ L-์„ธ๋ฆฐ์€ ๋ฒ ํƒ€-๋ฉ”ํ‹ธ์•„๋ฏธ๋…ธ-L-์•Œ๋ผ๋‹Œ์ด ์œ ๋„ํ•˜๋Š” ๋‡Œ์„ธํฌ ์‚ฌ๋ฉธ ํšจ์†Œ์˜ ์ฆ๊ฐ€๋ฅผ ์–ต์ œํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค. 

โ€Œโ€Œโ€Œโ€Œ๊ธฐ์–ต๋ ฅ๊ณผ ์ธ์ง€ ๋Šฅ๋ ฅ์„ ์ฆ์ง„ํ•˜๋Š” ๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ๊ณผ ํ›„ํผ์ง„A

๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ

๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ(ํ—ค๋ฆฌ์‹œ์›€ ์—๋ฆฌ๋‚˜์„ธ์šฐ์Šค, Hericium erinaceus)๋Š” ์‚ฌ์ž์˜ ๊ฐˆ๊ธฐ๋ฅผ ๋‹ฎ์€ ๊ธธ๊ณ  ๋งŽ์€ ํ•˜์–€์ƒ‰ ๋Œ๊ธฐ๊ฐ€ ํŠน์ง•์ž…๋‹ˆ๋‹ค. ์ผ๋ฐ˜์ ์œผ๋กœ ์•ผ์ƒ ๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ์€ ์ฉ์–ด๊ฐ€๋Š” ์ฃฝ์€ ์›๋ชฉ์—์„œ ์ž๋ผ๋Š”๋ฐ ์š”์ฆ˜์€ ์–‘์‹ํ•˜๋Š” ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์Šต๋‹ˆ๋‹ค. 

๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ์€ ๊ท ์‚ฌ์ฒด(๋•… ๋ฐ‘์— ์žˆ๋Š” ๋ฒ„์„ฏ์˜ ์ž์‹ค์ฒด ๋ถ€๋ถ„)์— ํ•จ์œ ๋œ ์—๋ฆฌ๋‚˜์‹ (Erinacine)์ด๋ผ๋Š” ํ™”ํ•ฉ๋ฌผ ๋“ฑ ๋‹ค์–‘ํ•œ ์ƒํ™œ์„ฑ ๋ฌผ์งˆ์ด ํ’๋ถ€ํ•ฉ๋‹ˆ๋‹ค. ์—๋ฆฌ๋‚˜์‹ ์€ ๋™๋ฌผ ๋ชจ๋ธ์˜ ํ˜ˆ์•ก๋‡Œ์žฅ๋ฒฝ(Blood-brain barrier)์„ ํ†ต๊ณผํ•˜์—ฌ ์ƒ๋‹นํ•œ ํšจ๋Šฅ์„ ๋ฐœํœ˜ํ•  ์ˆ˜ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ฐํ˜€์กŒ์Šต๋‹ˆ๋‹ค.24,25 ์ด ํ™”ํ•ฉ๋ฌผ์€ ๋‡Œ์™€ ์ฒ™์ˆ˜๋กœ ๊ตฌ์„ฑ๋˜๋Š” ์ค‘์ถ”์‹ ๊ฒฝ๊ณ„์˜ ํฌ๋Œ๊ธฐ๊ต์„ธํฌ(Oligodendrocyte)๋ฅผ ์ž๊ทนํ•ฉ๋‹ˆ๋‹ค.26

ํฌ๋Œ๊ธฐ๊ต์„ธํฌ๋Š” ์‹ ๊ฒฝ์„ธํฌ์˜ ์ถ•์‚ญ ๋ถ„์ ˆ์„ ๋‘˜๋Ÿฌ์‹ธ๋Š” ๋ฏธ์—˜๋ฆฐ ์ˆ˜์ดˆ(Myelin sheath)๋ฅผ ํ˜•์„ฑํ•˜๋Š” ๊ณผ์ •์ธ ๋ฏธ์—˜๋ฆฌ๋„ค์ด์…˜(Myelination)์„ ์ด‰์ง„ํ•ฉ๋‹ˆ๋‹ค. ๋ฏธ์—˜๋ฆฐ ์ˆ˜์ดˆ๋Š” ์ „๊ธฐ ์ž๊ทน์ด ์‹ ๊ฒฝ ๋ฐ ๋‡Œ์„ธํฌ๋ฅผ ๋”ฐ๋ผ ํšจ์œจ์ ์œผ๋กœ ๋นจ๋ฆฌ ์ „๋‹ฌ๋˜๋„๋ก ํ•˜๋Š” ์ ˆ์—ฐ์ธต์ž…๋‹ˆ๋‹ค. ๋‡Œ์—์„œ ๋ฏธ์—˜๋ฆฐ ์ˆ˜์ดˆ์˜ ์™„์ „์„ฑ ๋ฐ ๊ธฐ๋Šฅ์€ ์ •์ƒ์ ์ธ ๊ธฐ์–ต๋ ฅ, ์›€์ง์ž„, ์ธ์ง€๋ ฅ์— ๊ผญ ํ•„์š”ํ•œ ์š”์†Œ์ด๋ฉฐ ๋…ธํ™”๋œ ๋‡Œ์—์„œ ํŠนํžˆ ์ค‘์š”ํ•ฉ๋‹ˆ๋‹ค. 

์ด์ค‘๋งน๊ฒ€ ์œ„์•ฝ๋Œ€์กฐ ์ž„์ƒ์‹œํ—˜์—์„œ ๊ธฐ์–ต๋ ฅ๊ณผ ์ธ์ง€๋ ฅ์ด ์ €ํ•˜๋œ 50-80์„ธ์˜ ์ผ๋ณธ ์„ฑ์ธ ๋‚จ๋…€์—๊ฒŒ 16์ฃผ ๋™์•ˆ ๋งค์ผ 3ํšŒ ๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ ๊ฐ€๋ฃจ๊ฐ€ ๋“ค์–ด์žˆ๋Š” 250mg ์ •์ œ 4๊ฐœ๋ฅผ ํˆฌ์—ฌํ–ˆ์Šต๋‹ˆ๋‹ค.27 ์—ฐ๊ตฌ์ง„์€ ํˆฌ์—ฌ๊ฐ€ ๋๋‚œ ํ›„ 4์ฃผ๊ฐ„ ํ”ผํ—˜์ž๋ฅผ ์ถ”์  ๊ด€์ฐฐํ–ˆ์Šต๋‹ˆ๋‹ค. 

์ž„์ƒ์‹œํ—˜ 8์ฃผ ์ฐจ, 12์ฃผ ์ฐจ, 16์ฃผ ์ฐจ์— ๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ ๊ทธ๋ฃน์€ ์œ„์•ฝ ๊ทธ๋ฃน์— ๋น„ํ•ด ์ •์‹ ๊ธฐ๋Šฅ ์ ์ˆ˜๊ฐ€ ํฌ๊ฒŒ ํ–ฅ์ƒ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. 

ํ•˜์ง€๋งŒ ๋ณด์ถฉ์ด ๋๋‚œ ์ง€ 4์ฃผ๊ฐ€ ์ง€๋‚˜์ž ๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ์„ ์„ญ์ทจํ•œ ์‚ฌ๋žŒ์˜ ์ •์‹ ๊ธฐ๋Šฅ ์ ์ˆ˜๋Š” ํฌ๊ฒŒ ๊ฐ์†Œํ–ˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ๊ฒฐ๊ณผ๋กœ ๋ณผ ๋•Œ ๋‡Œ ๊ธฐ๋Šฅ ์ฆ์ง„ ํšจ๊ณผ๋ฅผ ์–ป์œผ๋ ค๋ฉด ๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ์„ ๊ณ„์† ๋ณด์ถฉํ•ด์•ผ ํ•จ์„ ์•Œ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. 

๋˜ ๋‹ค๋ฅธ ์ž„์ƒ์‹œํ—˜์—์„œ ๊ฒฝ๋ฏธํ•œ ์ธ์ง€ ์žฅ์• ๊ฐ€ ์žˆ๋Š” ๋…ธ์ธ์ด ๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ์„ ์„ญ์ทจํ–ˆ์„ ๋•Œ๋„ ๋น„์Šทํ•œ ํšจ๊ณผ๊ฐ€ ๋‚˜ํƒ€๋‚ฌ์Šต๋‹ˆ๋‹ค.28

ํ›„ํผ์ง„A

ํ›„ํผ์ง„A(Huperzine-A, Hup A)๋Š” ํ›„ํผ์ง€์•„ ์„ธ๋ผํƒ€(Huperzia Serrata)๋กœ๋„ ๋ถˆ๋ฆฌ๋Š” ์ค‘๊ตญ์‚ฐ ์„์†ก(Chinese Club Moss)์— ์ž์—ฐ์ ์œผ๋กœ ํ•จ์œ ๋œ ์•Œ์นผ๋ฆฌ์„ฑ ํ™”ํ•ฉ๋ฌผ์ž…๋‹ˆ๋‹ค. ํ›„ํผ์ง„A๋Š” ์—ฌ๋Ÿฌ ๊ฐ€์ง€ ์œ ์ตํ•œ ์ž‘์šฉ์„ ํ†ตํ•ด ๊ธฐ์–ต๋ ฅ ๋ฐ ์ธ์ง€๋ ฅ์ด ์ €ํ•˜๋œ ์‚ฌ๋žŒ์—๊ฒŒ ์ž„์ƒ์ ์œผ๋กœ ์˜๋ฏธ๊ฐ€ ์žˆ๋Š” ํšจ๊ณผ๋ฅผ ๋‚˜ํƒ€๋ƒ…๋‹ˆ๋‹ค.29,30 ํ›„ํผ์ง„A๋Š” ํšจ์†Œ์ธ ์•„์„ธํ‹ธ์ฝœ๋ฆฐ์—์Šคํ…Œ๋ผ์ œ(Acetylcholinesterase)๋ฅผ ๊ฐ€์—ญ์ ์œผ๋กœ ์ฐจ๋‹จํ•˜์—ฌ ์‹ ๊ฒฝ์ „๋‹ฌ๋ฌผ์งˆ์ธ ์•„์„ธํ‹ธ์ฝœ๋ฆฐ(Acetylcholine)์ด ๋ถ„ํ•ด๋˜์ง€ ์•Š๋„๋ก ํ•ฉ๋‹ˆ๋‹ค. 

๊ธฐ์–ต๋ ฅ ๋ฐ ์ง‘์ค‘๋ ฅ์ด ์ €ํ•˜๋œ ์‚ฌ๋žŒ์€ ์•„์„ธํ‹ธ์ฝœ๋ฆฐ์ด ๊ฒฐํ•๋œ ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์Šต๋‹ˆ๋‹ค. ํ›„ํผ์ง„A๋Š” ์•„์„ธํ‹ธ์ฝœ๋ฆฐ์ด ๋ถ„ํ•ด๋˜๋Š” ๊ฒƒ์„ ๋ฐฉ์ง€ํ•˜์—ฌ ์ธ์ง€๊ธฐ๋Šฅ ๋ฐ ๊ธฐ์–ต๋ ฅ์„ ์ฆ์ง„ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ ๋‹ค์–‘ํ•œ ์‹ ๊ฒฝ๋…์œผ๋กœ ์ธํ•œ ๋‡Œ์„ธํฌ ์†์ƒ์„ ๋ฐฉ์ง€ํ•˜๊ณ  ๋‡Œ์˜ ํ•ญ์‚ฐํ™” ํšจ์†Œ ํ™œ๋™์„ ์ฆ์ง„ํ•˜๋ฉฐ ์ƒˆ๋กœ์šด ๋‡Œ์„ธํฌ ํ˜•์„ฑ์„ ์ด‰์ง„ํ•ฉ๋‹ˆ๋‹ค. ์ผ๋ฐ˜์ ์œผ๋กœ ํ›„ํผ์ง„A๋Š” ๋งค์ผ 2ํšŒ 200mcg์„ ์„ญ์ทจํ•˜๋Š” ๊ฒƒ์ด ์ข‹์Šต๋‹ˆ๋‹ค. ์•ˆ์ „์„ฑ๊ณผ ํšจ๊ณผ๋ฅผ ์œ„ํ•ด ์ •์ œ๋˜์ง€ ์•Š์€ ํ›„ํผ์ง€์•„ ์ œ์ œ ๋Œ€์‹  ์ˆœ์ˆ˜ํ•œ ํ›„ํผ์ง„A๋ฅผ ์‚ฌ์šฉํ•˜์‹ญ์‹œ์˜ค. 

โ€Œโ€Œโ€Œโ€Œ๊ฒฐ๋ก : ํ•„์š”์— ๋”ฐ๋ฅธ ๋‡Œ ๊ธฐ๋Šฅ ์ฆ์ง„ ๋ฐฉ๋ฒ•

๋‡Œ ๊ธฐ๋Šฅ์ด ๋–จ์–ด์ง€๊ฑฐ๋‚˜ ๊ธฐ์–ต๋ ฅ์ด ๋‚˜๋น ์ง€๊ธฐ ์‹œ์ž‘ํ–ˆ๋‹ค๋ฉด ์ƒˆ๋กœ์šด ์‹๋‹จ, ์ƒํ™œ์Šต๊ด€, ๋ณด์ถฉ์ œ๋ฅผ ์ฑ„ํƒํ•˜๋Š” ๋“ฑ ์‹ ์†ํ•˜๊ณ  ์ ๊ทน์ ์ธ ๋Œ€์‘์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค. ํ˜ˆ์•ก ์ˆœํ™˜๋ฟ ์•„๋‹ˆ๋ผ ์ˆ™๋ฉด๊ณผ ์ŠคํŠธ๋ ˆ์Šค ๊ด€๋ฆฌ๋„ ๋‡Œ ๊ฑด๊ฐ•์— ์ค‘์š”ํ•œ ์š”์ธ์œผ๋กœ ์ž‘์šฉํ•ฉ๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ ์ด๋Ÿฌํ•œ ๋ถ€๋ถ„์—์„œ๋„ ๋ถ€์กฑํ•œ ์ ์ด ์—†๋„๋ก ์ตœ์„ ์„ ๋‹คํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค.

๋‡Œ ๊ธฐ๋Šฅ ๊ฐœ์„ ๊ณผ ๋‡Œ ๋…ธํ™” ์–ต์ œ์— ๋„์›€์ด ๋˜๋Š” ์ฃผ์š”ํ•œ ๋ณด์ถฉ์ œ๋ฅผ ์†Œ๊ฐœํ•ฉ๋‹ˆ๋‹ค. ์ฆ์ƒ์˜ ์ •๋„์— ๋”ฐ๋ผ ๋ณด์ถฉ์ œ๋“ค์„ ์ •๋ฆฌํ–ˆ์Šต๋‹ˆ๋‹ค.

์ •์ƒ: 1๋‹จ๊ณ„ ์ง€์›

๋‡Œ ๊ธฐ๋Šฅ ๋ฐ ๊ธฐ์–ต๋ ฅ์— ์ด์ƒ์ด ์—†์œผ๋ฉฐ ๊ทธ ์ƒํƒœ๋ฅผ ์œ ์ง€ํ•˜๊ณ  ์‹ถ์€ ๊ฒฝ์šฐ

๊ฒฝ์ฆ: 2๋‹จ๊ณ„ ์ง€์› 

๊ฑด๊ฐ•ํ•˜์ง€๋งŒ ๋‡Œ ๊ธฐ๋Šฅ์ด ๋–จ์–ด์ง€๊ฑฐ๋‚˜ ๋‹จ๊ธฐ ๊ธฐ์–ต๋ ฅ์ด ๋‚˜๋น ์ง„ ๊ฒƒ ๊ฐ™์€ ๊ฒฝ์šฐ

  • 1๋‹จ๊ณ„์˜ ๋ณด์ถฉ์ œ๋ฅผ ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค
  •  ๋ฉคํ‘ธ๋“œ(Mem Food) 1์Šค์ฟฑ ๋˜๋Š” 1ํŒจํ‚ท์„ ๋งค์ผ ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค. 1ํšŒ ์ œ๊ณต๋Ÿ‰์˜ ์˜์–‘์„ฑ๋ถ„ ํ•จ๋Ÿ‰์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.
    • L-์„ธ๋ฆฐ: 4.2g
    • ์œ ๊ธฐ๋† ๋…ธ๋ฃจ๊ถ๋Ž…์ด๋ฒ„์„ฏ(์œ ๊ธฐ๋† ๊ท€๋ฆฌ๋กœ ๋ฐฐ์–‘ํ•œ ๊ท ์‚ฌ์ฒด ๋ฐ”์ด์˜ค๋งค์Šค์™€ ์ž์‹ค์ฒด): 2g
    • ๋ธ”๋ฃจ๋ฒ ๋ฆฌ(๋ฐ”ํ‚ค๋‹ˆ์›€ ์ฝ”๋ฆผ๋ณด์ˆจ, Vaccinium corymbosum) ์ฃผ์Šค ๋ถ„๋ง: 2g
    • MEM ๋ฐฐํ•ฉ๋ฌผ    290mg
      • ์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด(์•„์„ธํ‹ธ-L-์นด๋ฅด๋‹ˆํ‹ด์—ผ์‚ฐ์—ผ), ์œ ๊ธฐ๋† ๊ฐ•ํ™ฉ(Curcuma longa, ์ปคํ๋งˆ ๋กฑ๊ฐ€) ๋ฟŒ๋ฆฌ ์ถ”์ถœ๋ฌผ, ํŠธ๋žœ์Šค ๋ ˆ์Šค๋ฒ ๋ผํŠธ๋กค(ํด๋ฆฌ๊ณ ๋ˆ” ์ฟ ์Šคํ”ผ๋‹คํˆผ ๋ฟŒ๋ฆฌ ์ถ”์ถœ๋ฌผ), ํ”„๋ž‘์Šค ํ•ด์†ก(ํ”ผ๋ˆ„์Šค ํ”ผ๋‚˜์Šคํ„ฐ, Pinus pinaster) ๊ป์งˆ ์ถ”์ถœ๋ฌผ, ํ”ผ๋กค๋กœํ€ด๋†€๋ฆฐ ํ€ด๋…ผ ๋””๋‚˜ํŠธ๋ฅจ์—ผ
  • ์ฝ”ํํ…: ์œ ๋น„ํ€ด๋†€(Ubiquinol) ํ˜•ํƒœ๋Š” 100m, ์œ ๋น„ํ€ด๋…ผ(Ubiquinone) ํ˜•ํƒœ๋Š” 300mg์„ ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค.

์ค‘์ฆ: 3๋‹จ๊ณ„ ์ง€์› 

๋‡Œ ๊ธฐ๋Šฅ๊ณผ ๊ธฐ์–ต๋ ฅ์— ์‹ฌ๊ฐํ•œ ๋ฌธ์ œ๊ฐ€ ์ƒ๊ธด ๊ฒฝ์šฐ

  • ๋‹ค์Œ์ฒ˜๋Ÿผ ์šฉ๋Ÿ‰์„ ๋Š˜๋ ค 1๋‹จ๊ณ„์™€ 2๋‹จ๊ณ„์˜ ๋ณด์ถฉ์ œ๋ฅผ ๋ชจ๋‘ ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค.
    • ๋ฉคํ‘ธ๋“œ(Mem Food): 1์Šค์ฟฑ ๋˜๋Š” 1ํŒจํ‚ท์„ ๋งค์ผ 2ํšŒ ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค.
    • ํ”ผ์‰ฌ ์˜ค์ผ ๋ณด์ถฉ์ œ: ์—์ด์ฝ”์‚ฌํŽœํƒ€์—”์‚ฐ, ๋„์ฝ”์‚ฌํ—ฅ์‚ฌ์—”์‚ฐ, ๋„์ฝ”์‚ฌํŽœํƒ€์—”์‚ฐ(Docosapentaenoic acid, DPA)์„ ๋งค์ผ 1,000-2,000mg ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค. 
    • ์ปคํ๋ฏผ: ๋งค์ผ 180mg ์„ญ์ทจํ•ฉ๋‹ˆ๋‹ค.
  • ๋‹ค์Œ์„ ์ถ”๊ฐ€๋กœ ๋“œ์‹ญ์‹œ์˜ค.

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๋ฉด์ฑ…์‚ฌํ•ญ:์›ฐ๋‹ˆ์Šค ํ—ˆ๋ธŒ์˜ ์ทจ์ง€๋Š” ์˜ํ•™์ ์ธ ์ง„๋‹จ์ด๋‚˜ ์น˜๋ฃŒ๋ฅผ ์ œ๊ณตํ•˜๋Š” ๊ฒƒ์ด ์•„๋‹™๋‹ˆ๋‹ค. ์ž์„ธํžˆ ์•Œ์•„๋ณด๊ธฐ